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Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody.
Weaver JD, Stack EC, Buggé JA, Hu C, McGrath L, Mueller A, Wong M, Klebanov B, Rahman T, Kaufman R, Fregeau C, Spaulding V, Priess M, Legendre K, Jaffe S, Upadhyay D, Singh A, Xu CA, Krukenberg K, Zhang Y, Ezzyat Y, Saddier Axe D, Kuhne MR, Meehl MA, Shaffer DR, Weist BM, Wiederschain D, Depis F, Gostissa M. Weaver JD, et al. Among authors: legendre k. Oncoimmunology. 2022 Nov 4;11(1):2141007. doi: 10.1080/2162402X.2022.2141007. eCollection 2022. Oncoimmunology. 2022. PMID: 36352891 Free PMC article.
Mmp12 Is Upregulated by in utero Second-Hand Smoke Exposures and Is a Key Factor Contributing to Aggravated Lung Responses in Adult Emphysema, Asthma, and Lung Cancer Mouse Models.
Noël A, Perveen Z, Xiao R, Hammond H, Le Donne V, Legendre K, Gartia MR, Sahu S, Paulsen DB, Penn AL. Noël A, et al. Among authors: legendre k. Front Physiol. 2021 Nov 29;12:704401. doi: 10.3389/fphys.2021.704401. eCollection 2021. Front Physiol. 2021. PMID: 34912233 Free PMC article.
Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function.
Harmon AC, Noël A, Subramanian B, Perveen Z, Jennings MH, Chen YF, Penn AL, Legendre K, Paulsen DB, Varner KJ, Dugas TR. Harmon AC, et al. Among authors: legendre k. Am J Physiol Heart Circ Physiol. 2021 Oct 1;321(4):H667-H683. doi: 10.1152/ajpheart.00725.2020. Epub 2021 Aug 20. Am J Physiol Heart Circ Physiol. 2021. PMID: 34415187 Free PMC article.
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