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Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter.
Porée B, Kypriotou M, Chadjichristos C, Beauchef G, Renard E, Legendre F, Melin M, Gueret S, Hartmann DJ, Malléin-Gerin F, Pujol JP, Boumediene K, Galéra P. Porée B, et al. Among authors: legendre f. J Biol Chem. 2008 Feb 22;283(8):4850-65. doi: 10.1074/jbc.M706387200. Epub 2007 Dec 7. J Biol Chem. 2008. PMID: 18065760 Free article.
Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes.
Renard E, Porée B, Chadjichristos C, Kypriotou M, Maneix L, Bigot N, Legendre F, Ollitrault D, De Crombrugghe B, Malléin-Gérin F, Moslemi S, Demoor M, Boumediene K, Galéra P. Renard E, et al. Among authors: legendre f. J Mol Med (Berl). 2012 Jun;90(6):649-66. doi: 10.1007/s00109-011-0842-3. Epub 2012 Jan 4. J Mol Med (Berl). 2012. PMID: 22215151
Enhanced hyaline cartilage matrix synthesis in collagen sponge scaffolds by using siRNA to stabilize chondrocytes phenotype cultured with bone morphogenetic protein-2 under hypoxia.
Legendre F, Ollitrault D, Hervieu M, Baugé C, Maneix L, Goux D, Chajra H, Mallein-Gerin F, Boumediene K, Galera P, Demoor M. Legendre F, et al. Tissue Eng Part C Methods. 2013 Jul;19(7):550-67. doi: 10.1089/ten.TEC.2012.0508. Epub 2013 Feb 19. Tissue Eng Part C Methods. 2013. PMID: 23270543
Cartilage tissue engineering: molecular control of chondrocyte differentiation for proper cartilage matrix reconstruction.
Demoor M, Ollitrault D, Gomez-Leduc T, Bouyoucef M, Hervieu M, Fabre H, Lafont J, Denoix JM, Audigié F, Mallein-Gerin F, Legendre F, Galera P. Demoor M, et al. Among authors: legendre f. Biochim Biophys Acta. 2014 Aug;1840(8):2414-40. doi: 10.1016/j.bbagen.2014.02.030. Epub 2014 Mar 6. Biochim Biophys Acta. 2014. PMID: 24608030 Review.
BMP-2, hypoxia, and COL1A1/HtrA1 siRNAs favor neo-cartilage hyaline matrix formation in chondrocytes.
Ollitrault D, Legendre F, Drougard C, Briand M, Benateau H, Goux D, Chajra H, Poulain L, Hartmann D, Vivien D, Shridhar V, Baldi A, Mallein-Gerin F, Boumediene K, Demoor M, Galera P. Ollitrault D, et al. Among authors: legendre f. Tissue Eng Part C Methods. 2015 Feb;21(2):133-47. doi: 10.1089/ten.TEC.2013.0724. Epub 2014 Jul 31. Tissue Eng Part C Methods. 2015. PMID: 24957638 Free PMC article.
92 results