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Molecular details of ruthenium red pore block in TRPV channels.
Pumroy RA, De Jesús-Pérez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V. Pumroy RA, et al. Among authors: leffler a. EMBO Rep. 2024 Feb;25(2):506-523. doi: 10.1038/s44319-023-00050-0. Epub 2024 Jan 15. EMBO Rep. 2024. PMID: 38225355 Free PMC article.
Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2.
Fricke TC, Echtermeyer F, Zielke J, de la Roche J, Filipovic MR, Claverol S, Herzog C, Tominaga M, Pumroy RA, Moiseenkova-Bell VY, Zygmunt PM, Leffler A, Eberhardt MJ. Fricke TC, et al. Among authors: leffler a. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24359-24365. doi: 10.1073/pnas.1904332116. Epub 2019 Nov 12. Proc Natl Acad Sci U S A. 2019. PMID: 31719194 Free PMC article.
Structural insights into TRPV2 activation by small molecules.
Pumroy RA, Protopopova AD, Fricke TC, Lange IU, Haug FM, Nguyen PT, Gallo PN, Sousa BB, Bernardes GJL, Yarov-Yarovoy V, Leffler A, Moiseenkova-Bell VY. Pumroy RA, et al. Among authors: leffler a. Nat Commun. 2022 Apr 28;13(1):2334. doi: 10.1038/s41467-022-30083-3. Nat Commun. 2022. PMID: 35484159 Free PMC article.
Functional and structural insights into activation of TRPV2 by weak acids.
Haug FM, Pumroy RA, Sridhar A, Pantke S, Dimek F, Fricke TC, Hage A, Herzog C, Echtermeyer FG, de la Roche J, Koh A, Kotecha A, Howard RJ, Lindahl E, Moiseenkova-Bell V, Leffler A. Haug FM, et al. Among authors: leffler a. EMBO J. 2024 Apr 26. doi: 10.1038/s44318-024-00106-4. Online ahead of print. EMBO J. 2024. PMID: 38671253 Free article.
Lactate is a potent inhibitor of the capsaicin receptor TRPV1.
de la Roche J, Walther I, Leonow W, Hage A, Eberhardt M, Fischer M, Reeh PW, Sauer S, Leffler A. de la Roche J, et al. Among authors: leffler a. Sci Rep. 2016 Nov 9;6:36740. doi: 10.1038/srep36740. Sci Rep. 2016. PMID: 27827430 Free PMC article.
183 results