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Functional and structural insights into activation of TRPV2 by weak acids.
Haug FM, Pumroy RA, Sridhar A, Pantke S, Dimek F, Fricke TC, Hage A, Herzog C, Echtermeyer FG, de la Roche J, Koh A, Kotecha A, Howard RJ, Lindahl E, Moiseenkova-Bell V, Leffler A. Haug FM, et al. Among authors: leffler a. EMBO J. 2024 Apr 26. doi: 10.1038/s44318-024-00106-4. Online ahead of print. EMBO J. 2024. PMID: 38671253 Free article.
Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity.
Carney DW, Leffler AE, Bell JA, Chandrasinghe AS, Cheng C, Chang E, Dornford A, Dougan DR, Frye LL, Grimes ME, Knehans T, Knight JL, Komandla M, Lane W, Li H, Newman SR, Phimister K, Saikatendu KS, Silverstein H, Vafaei S. Carney DW, et al. Among authors: leffler ae. Bioorg Med Chem. 2024 Apr 1;103:117577. doi: 10.1016/j.bmc.2023.117577. Epub 2024 Jan 5. Bioorg Med Chem. 2024. PMID: 38518735 Free article.
Molecular details of ruthenium red pore block in TRPV channels.
Pumroy RA, De Jesús-Pérez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V. Pumroy RA, et al. Among authors: leffler a. EMBO Rep. 2024 Feb;25(2):506-523. doi: 10.1038/s44319-023-00050-0. Epub 2024 Jan 15. EMBO Rep. 2024. PMID: 38225355 Free PMC article.
Basic Residues at Position 11 of α-Conotoxin LvIA Influence Subtype Selectivity between α3β2 and α3β4 Nicotinic Receptors via an Electrostatic Mechanism.
Haufe Y, Kuruva V, Samanani Z, Lokaj G, Kamnesky G, Shadamarshan P, Shahoei R, Katz D, Sampson JM, Pusch M, Brik A, Nicke A, Leffler AE. Haufe Y, et al. Among authors: leffler ae. ACS Chem Neurosci. 2023 Dec 20;14(24):4311-4322. doi: 10.1021/acschemneuro.3c00506. Epub 2023 Dec 5. ACS Chem Neurosci. 2023. PMID: 38051211
Free heme and hemopexin in acute kidney injury after cardiopulmonary bypass and transient renal ischemia.
Greite R, Schott S, Wang L, Gohlke L, Kreimann K, Derlin K, Gutberlet M, Schmidbauer M, Leffler A, Tudorache I, Salman J, Ius F, Natanov R, Fegbeutel C, Haverich A, Lichtinghagen R, Hüsing AM, von Vietinghoff S, Schmitt R, Shushakova N, Rong S, Haller H, Schmidt-Ott KM, Gram M, Vijayan V, Scheffner I, Gwinner W, Immenschuh S. Greite R, et al. Among authors: leffler a. Clin Transl Sci. 2023 Dec;16(12):2729-2743. doi: 10.1111/cts.13667. Epub 2023 Oct 30. Clin Transl Sci. 2023. PMID: 37899696 Free PMC article.
183 results