Leffler A - Search Results

1

Comparing human iPSC-cardiomyocytes versus HEK293T cells unveils disease-causing effects of Brugada mutation A735V of Na_V1.5 sodium channels.

de la Roche J, Angsutararux P, Kempf H, Janan M, Bolesani E, Thiemann S, Wojciechowski D, Coffee M, Franke A, Schwanke K, Leffler A, Luanpitpong S, Issaragrisil S, Fischer M, Zweigerdt R. de la Roche J, et al. Among authors: leffler a. Sci Rep. 2019 Aug 1;9(1):11173. doi: 10.1038/s41598-019-47632-4. Sci Rep. 2019. PMID: 31371804 Free PMC article.

2

Defective polysialylation and sialylation induce opposite effects on gating of the skeletal Na+ channel NaV1.4 in Chinese hamster ovary cells.

Ahrens J, Foadi N, Eberhardt A, Haeseler G, Dengler R, Leffler A, Mühlenhoff M, Gerardy-Schahn R, Leuwer M. Ahrens J, et al. Among authors: leffler a. Pharmacology. 2011;87(5-6):311-7. doi: 10.1159/000327389. Epub 2011 May 21. Pharmacology. 2011. PMID: 21606664

3

Interaction of alfaxalone with the neuronal and the skeletal muscle sodium channel.

Foadi N, Pilawski I, Buchholz V, de la Roche J, Wegner F, Leffler A, Ahrens J, Kästner S. Foadi N, et al. Among authors: leffler a. Pharmacology. 2012;89(5-6):295-302. doi: 10.1159/000337737. Pharmacology. 2012. PMID: 22538831

4

The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6.

de la Roche J, Eberhardt MJ, Klinger AB, Stanslowsky N, Wegner F, Koppert W, Reeh PW, Lampert A, Fischer MJ, Leffler A. de la Roche J, et al. Among authors: leffler a. J Biol Chem. 2013 Jul 12;288(28):20280-92. doi: 10.1074/jbc.M113.479337. Epub 2013 May 24. J Biol Chem. 2013. PMID: 23709225 Free PMC article.

5

The distinct effects of lipid emulsions used for "lipid resuscitation" on gating and bupivacaine-induced inhibition of the cardiac sodium channel Nav1.5.

Nadrowitz F, Stoetzer C, Foadi N, Ahrens J, Wegner F, Lampert A, Koppert W, de la Roche J, Leffler A. Nadrowitz F, et al. Among authors: leffler a. Anesth Analg. 2013 Nov;117(5):1101-8. doi: 10.1213/ANE.0b013e3182a1af78. Anesth Analg. 2013. PMID: 24029851

6

The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na⁺ channel, Na(v)1.5.

Schulze V, Stoetzer C, O'Reilly AO, Eberhardt E, Foadi N, Ahrens J, Wegner F, Lampert A, de la Roche J, Leffler A. Schulze V, et al. Among authors: leffler a. Br J Pharmacol. 2014 Jan;171(2):427-37. doi: 10.1111/bph.12465. Br J Pharmacol. 2014. PMID: 24117196 Free PMC article.

7

Inhibition of the cardiac Na⁺ channel α-subunit Nav1.5 by propofol and dexmedetomidine.

Stoetzer C, Reuter S, Doll T, Foadi N, Wegner F, Leffler A. Stoetzer C, et al. Among authors: leffler a. Naunyn Schmiedebergs Arch Pharmacol. 2016 Mar;389(3):315-25. doi: 10.1007/s00210-015-1195-1. Epub 2015 Dec 15. Naunyn Schmiedebergs Arch Pharmacol. 2016. PMID: 26667357

8

Tetrodotoxin-sensitive α-subunits of voltage-gated sodium channels are relevant for inhibition of cardiac sodium currents by local anesthetics.

Stoetzer C, Doll T, Stueber T, Herzog C, Echtermeyer F, Greulich F, Rudat C, Kispert A, Wegner F, Leffler A. Stoetzer C, et al. Among authors: leffler a. Naunyn Schmiedebergs Arch Pharmacol. 2016 Jun;389(6):625-36. doi: 10.1007/s00210-016-1231-9. Epub 2016 Mar 22. Naunyn Schmiedebergs Arch Pharmacol. 2016. PMID: 27000037

9

Local-anesthetic like inhibition of the cardiac sodium channel Nav1.5 α-subunit by 5-HT3 receptor antagonists.

Van't Klooster MP, Foadi N, Hage A, Stoetzer C, Wegner F, Eberhardt M, Leffler A. Van't Klooster MP, et al. Among authors: leffler a. Eur J Pharmacol. 2016 Oct 15;789:119-126. doi: 10.1016/j.ejphar.2016.07.020. Epub 2016 Jul 9. Eur J Pharmacol. 2016. PMID: 27401036

10

Oxidation differentially modulates the recombinant voltage-gated Na(+) channel α-subunits Nav1.7 and Nav1.8.

Schlüter F, Leffler A. Schlüter F, et al. Among authors: leffler a. Brain Res. 2016 Oct 1;1648(Pt A):127-135. doi: 10.1016/j.brainres.2016.07.031. Epub 2016 Jul 19. Brain Res. 2016. PMID: 27450927

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