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FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.
Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, Peretti N, Rabasa-Lhoret R, Laville M, Vidal H, Rieusset J. Bravard A, et al. Among authors: lefai e. Diabetes. 2011 Jan;60(1):258-68. doi: 10.2337/db10-0281. Epub 2010 Oct 13. Diabetes. 2011. PMID: 20943749 Free PMC article.
Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice.
Aswad H, Forterre A, Wiklander OP, Vial G, Danty-Berger E, Jalabert A, Lamazière A, Meugnier E, Pesenti S, Ott C, Chikh K, El-Andaloussi S, Vidal H, Lefai E, Rieusset J, Rome S. Aswad H, et al. Among authors: lefai e. Diabetologia. 2014 Oct;57(10):2155-64. doi: 10.1007/s00125-014-3337-2. Epub 2014 Jul 30. Diabetologia. 2014. PMID: 25073444 Free PMC article.
The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway.
Granjon A, Gustin MP, Rieusset J, Lefai E, Meugnier E, Güller I, Cerutti C, Paultre C, Disse E, Rabasa-Lhoret R, Laville M, Vidal H, Rome S. Granjon A, et al. Among authors: lefai e. Diabetes. 2009 Nov;58(11):2555-64. doi: 10.2337/db09-0165. Epub 2009 Aug 31. Diabetes. 2009. PMID: 19720801 Free PMC article.
Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation.
Eljaafari A, Robert M, Chehimi M, Chanon S, Durand C, Vial G, Bendridi N, Madec AM, Disse E, Laville M, Rieusset J, Lefai E, Vidal H, Pirola L. Eljaafari A, et al. Among authors: lefai e. Diabetes. 2015 Jul;64(7):2477-88. doi: 10.2337/db15-0162. Epub 2015 Mar 12. Diabetes. 2015. PMID: 25765019
78 results