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An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis.
Vugler A, O'Connell J, Nguyen MA, Weitz D, Leeuw T, Hickford E, Verbitsky A, Ying X, Rehberg M, Carrington B, Merriman M, Moss A, Nicholas JM, Stanley P, Wright S, Bourne T, Foricher Y, Brookings D, Horsley H, Herrmann M, Rao S, Kohlmann M, Florian P. Vugler A, et al. Among authors: leeuw t. Front Pharmacol. 2022 Nov 16;13:1037983. doi: 10.3389/fphar.2022.1037983. eCollection 2022. Front Pharmacol. 2022. PMID: 36467083 Free PMC article.
Neutrophilic granulocyte-derived B-cell activating factor supports B cells in skin lesions in hidradenitis suppurativa.
Sabat R, Šimaitė D, Gudjonsson JE, Brembach TC, Witte K, Krause T, Kokolakis G, Bartnik E, Nikolaou C, Rill N, Coulibaly B, Levin C, Herrmann M, Salinas G, Leeuw T, Volk HD, Ghoreschi K, Wolk K. Sabat R, et al. Among authors: leeuw t. J Allergy Clin Immunol. 2023 Apr;151(4):1015-1026. doi: 10.1016/j.jaci.2022.10.034. Epub 2022 Dec 5. J Allergy Clin Immunol. 2023. PMID: 36481267
The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: A potential disease-modifying OA drug.
Drummond SP, Bartnik E, Kouvatsos N, Scott JL, Dyer DP, Thomson JM, Price AJ, Anand S, Biant LC, Leeuw T, Herrmann M, Milner CM, Day AJ. Drummond SP, et al. Among authors: leeuw t. Osteoarthritis Cartilage. 2023 Oct;31(10):1353-1364. doi: 10.1016/j.joca.2023.05.013. Epub 2023 May 29. Osteoarthritis Cartilage. 2023. PMID: 37257556 Free article.
Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγnull mice reconstituted with human peripheral blood mononuclear cells.
Jodeleit H, Winkelmann P, Caesar J, Sterz S, Holdt LM, Beigel F, Stallhofer J, Breiteneicher S, Bartnik E, Leeuw T, Siebeck M, Gropp R. Jodeleit H, et al. Among authors: leeuw t. Dis Model Mech. 2021 Jan 1;14(1):dmm046995. doi: 10.1242/dmm.046995. Epub 2021 Jan 21. Dis Model Mech. 2021. PMID: 33293281 Free PMC article.
Enzymatic Synthesis of Copolyesters with the Heteroaromatic Diol 3,4-Bis(hydroxymethyl)furan and Isomeric Dimethyl Furandicarboxylate Substitutions.
Silvianti F, Maniar D, Agostinho B, de Leeuw TC, Woortman AJJ, van Dijken J, Thiyagarajan S, Sousa AF, Loos K. Silvianti F, et al. Among authors: de leeuw tc. Biomacromolecules. 2024 May 13;25(5):2792-2802. doi: 10.1021/acs.biomac.3c01433. Epub 2024 Apr 11. Biomacromolecules. 2024. PMID: 38602263 Free PMC article.
A Dutch paediatric palliative care guideline: a systematic review and evidence-based recommendations for symptom treatment.
van Teunenbroek KC, Mulder RL, Ahout IML, Bindels-de Heus KGCB, Delsman-van Gelder CM, Galimont-Collen AFS, de Groot MAR, Heitink-Polle KMJ, Looijestijn J, Mensink MO, Mulder S, Schieving JH, Schouten-van Meeteren AYN, Verheijden JMA, Rippen H, Borggreve BCM, Kremer LCM, Verhagen AAE, Michiels EMC; working groups symptom treatment and refractory symptom treatment of the Dutch paediatric palliative care guideline. van Teunenbroek KC, et al. BMC Palliat Care. 2024 Mar 13;23(1):72. doi: 10.1186/s12904-024-01367-w. BMC Palliat Care. 2024. PMID: 38481215 Free PMC article.
71 results