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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.
van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB. van der Kant R, et al. Among authors: leestemaker y. Cell Stem Cell. 2019 Mar 7;24(3):363-375.e9. doi: 10.1016/j.stem.2018.12.013. Epub 2019 Jan 24. Cell Stem Cell. 2019. PMID: 30686764 Free PMC article.
Hitting the target.
Leestemaker Y, Ovaa H. Leestemaker Y, et al. Nat Methods. 2015 Dec;12(12):1127-8. doi: 10.1038/nmeth.3660. Nat Methods. 2015. PMID: 26624797 No abstract available.
Tools to investigate the ubiquitin proteasome system.
Leestemaker Y, Ovaa H. Leestemaker Y, et al. Drug Discov Today Technol. 2017 Dec;26:25-31. doi: 10.1016/j.ddtec.2017.11.006. Epub 2017 Nov 26. Drug Discov Today Technol. 2017. PMID: 29249239 Free article. Review.
Proteasome Activation by Small Molecules.
Leestemaker Y, de Jong A, Witting KF, Penning R, Schuurman K, Rodenko B, Zaal EA, van de Kooij B, Laufer S, Heck AJR, Borst J, Scheper W, Berkers CR, Ovaa H. Leestemaker Y, et al. Cell Chem Biol. 2017 Jun 22;24(6):725-736.e7. doi: 10.1016/j.chembiol.2017.05.010. Epub 2017 May 25. Cell Chem Biol. 2017. PMID: 28552582 Free article.
Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.
Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR 3rd, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT. Widjaja CE, et al. Among authors: leestemaker y. J Clin Invest. 2017 Oct 2;127(10):3609-3623. doi: 10.1172/JCI90895. Epub 2017 Aug 28. J Clin Invest. 2017. PMID: 28846070 Free PMC article.