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A proteogenomic signature of age-related macular degeneration in blood.
Emilsson V, Gudmundsson EF, Jonmundsson T, Jonsson BG, Twarog M, Gudmundsdottir V, Li Z, Finkel N, Poor S, Liu X, Esterberg R, Zhang Y, Jose S, Huang CL, Liao SM, Loureiro J, Zhang Q, Grosskreutz CL, Nguyen AA, Huang Q, Leehy B, Pitts R, Aspelund T, Lamb JR, Jonasson F, Launer LJ, Cotch MF, Jennings LL, Gudnason V, Walshe TE. Emilsson V, et al. Among authors: leehy b. Nat Commun. 2022 Jun 13;13(1):3401. doi: 10.1038/s41467-022-31085-x. Nat Commun. 2022. PMID: 35697682 Free PMC article.
Long-acting protein drugs for the treatment of ocular diseases.
Ghosh JG, Nguyen AA, Bigelow CE, Poor S, Qiu Y, Rangaswamy N, Ornberg R, Jackson B, Mak H, Ezell T, Kenanova V, de la Cruz E, Carrion A, Etemad-Gilbertson B, Caro RG, Zhu K, George V, Bai J, Sharma-Nahar R, Shen S, Wang Y, Subramanian KK, Fassbender E, Maker M, Hanks S, Vrouvlianis J, Leehy B, Long D, Prentiss M, Kansara V, Jaffee B, Dryja TP, Roguska M. Ghosh JG, et al. Among authors: leehy b. Nat Commun. 2017 Mar 23;8:14837. doi: 10.1038/ncomms14837. Nat Commun. 2017. PMID: 28332616 Free PMC article.
The Hierarchy of Proinflammatory Cytokines in Ocular Inflammation.
Da Cunha AP, Zhang Q, Prentiss M, Wu XQ, Kainz V, Xu YY, Vrouvlianis J, Li H, Rangaswamy N, Leehy B, McGee TL, Bell CL, Bigelow CE, Kansara V, Medley Q, Huang Q, Wu HY. Da Cunha AP, et al. Among authors: leehy b. Curr Eye Res. 2018 Apr;43(4):553-565. doi: 10.1080/02713683.2017.1410180. Epub 2017 Dec 4. Curr Eye Res. 2018. PMID: 29199855
ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrprd6 mouse.
Sluch VM, Banks A, Li H, Crowley MA, Davis V, Xiang C, Yang J, Demirs JT, Vrouvlianis J, Leehy B, Hanks S, Hyman AM, Aranda J, Chang B, Bigelow CE, Rice DS. Sluch VM, et al. Among authors: leehy b. Sci Rep. 2018 Sep 25;8(1):14339. doi: 10.1038/s41598-018-32579-9. Sci Rep. 2018. PMID: 30254279 Free PMC article.
AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice.
Choi VW, Bigelow CE, McGee TL, Gujar AN, Li H, Hanks SM, Vrouvlianis J, Maker M, Leehy B, Zhang Y, Aranda J, Bounoutas G, Demirs JT, Yang J, Ornberg R, Wang Y, Martin W, Stout KR, Argentieri G, Grosenstein P, Diaz D, Turner O, Jaffee BD, Police SR, Dryja TP. Choi VW, et al. Among authors: leehy b. Mol Ther Methods Clin Dev. 2015 Jul 8;2:15022. doi: 10.1038/mtm.2015.22. eCollection 2015. Mol Ther Methods Clin Dev. 2015. PMID: 26199951 Free PMC article.
Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells.
Lynch JM, Li B, Katoli P, Xiang C, Leehy B, Rangaswamy N, Saenz-Vash V, Wang YK, Lei H, Nicholson TB, Meredith E, Rice DS, Prasanna G, Chen A. Lynch JM, et al. Among authors: leehy b. J Biol Chem. 2018 Dec 28;293(52):20137-20156. doi: 10.1074/jbc.RA118.004325. Epub 2018 Nov 2. J Biol Chem. 2018. PMID: 30389787 Free PMC article.
Genetic variations strongly influence phenotypic outcome in the mouse retina.
Jelcick AS, Yuan Y, Leehy BD, Cox LC, Silveira AC, Qiu F, Schenk S, Sachs AJ, Morrison MA, Nystuen AM, DeAngelis MM, Haider NB. Jelcick AS, et al. Among authors: leehy bd. PLoS One. 2011;6(7):e21858. doi: 10.1371/journal.pone.0021858. Epub 2011 Jul 14. PLoS One. 2011. PMID: 21779340 Free PMC article.