Leedham SJ - Search Results

1

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification.

Kleeman SO, Koelzer VH, Jones HJ, Vazquez EG, Davis H, East JE, Arnold R, Koppens MA, Blake A, Domingo E, Cunningham C, Beggs AD, Pestinger V, Loughrey MB, Wang LM, Lannagan TR, Woods SL, Worthley D, Consortium SC, Tomlinson I, Dunne PD, Maughan T, Leedham SJ. Kleeman SO, et al. Among authors: leedham sj. Gut. 2020 Jun;69(6):1092-1103. doi: 10.1136/gutjnl-2019-319126. Epub 2019 Sep 28. Gut. 2020. PMID: 31563876 Free PMC article.

2

APC and the three-hit hypothesis.

Segditsas S, Rowan AJ, Howarth K, Jones A, Leedham S, Wright NA, Gorman P, Chambers W, Domingo E, Roylance RR, Sawyer EJ, Sieber OM, Tomlinson IP. Segditsas S, et al. Oncogene. 2009 Jan 8;28(1):146-55. doi: 10.1038/onc.2008.361. Epub 2008 Oct 6. Oncogene. 2009. PMID: 18836487

3

Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.

Thirlwell C, Will OC, Domingo E, Graham TA, McDonald SA, Oukrif D, Jeffrey R, Gorman M, Rodriguez-Justo M, Chin-Aleong J, Clark SK, Novelli MR, Jankowski JA, Wright NA, Tomlinson IP, Leedham SJ. Thirlwell C, et al. Among authors: leedham sj. Gastroenterology. 2010 Apr;138(4):1441-54, 1454.e1-7. doi: 10.1053/j.gastro.2010.01.033. Epub 2010 Jan 25. Gastroenterology. 2010. PMID: 20102718

4

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.

Leedham SJ, Rodenas-Cuadrado P, Howarth K, Lewis A, Mallappa S, Segditsas S, Davis H, Jeffery R, Rodriguez-Justo M, Keshav S, Travis SP, Graham TA, East J, Clark S, Tomlinson IP. Leedham SJ, et al. Gut. 2013 Jan;62(1):83-93. doi: 10.1136/gutjnl-2011-301601. Epub 2012 Jan 27. Gut. 2013. PMID: 22287596 Free PMC article.

5

The continuum model of selection in human tumors: general paradigm or niche product?

Leedham S, Tomlinson I. Leedham S, et al. Cancer Res. 2012 Jul 1;72(13):3131-4. doi: 10.1158/0008-5472.CAN-12-1052. Epub 2012 May 2. Cancer Res. 2012. PMID: 22552286 Free article.

6

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.

Jaeger E, Leedham S, Lewis A, Segditsas S, Becker M, Cuadrado PR, Davis H, Kaur K, Heinimann K, Howarth K; HMPS Collaboration; East J, Taylor J, Thomas H, Tomlinson I. Jaeger E, et al. Nat Genet. 2012 May 6;44(6):699-703. doi: 10.1038/ng.2263. Nat Genet. 2012. PMID: 22561515 Free PMC article.

7

Reply to "The classification of intestinal polyposis".

Tomlinson I, Jaeger E, Leedham S, Thomas H. Tomlinson I, et al. Nat Genet. 2013 Jan;45(1):2-3. doi: 10.1038/ng.2475. Nat Genet. 2013. PMID: 23268126 No abstract available.

8

Diagnosis of sessile serrated polyps/adenomas: what does this mean for the pathologist, gastroenterologist and patient?

Leedham S, East JE, Chetty R. Leedham S, et al. J Clin Pathol. 2013 Apr;66(4):265-8. doi: 10.1136/jclinpath-2013-201457. Epub 2013 Feb 12. J Clin Pathol. 2013. PMID: 23404799 Review. No abstract available.

9

Reporting trends of right-sided hyperplastic and sessile serrated polyps in a large teaching hospital over a 4-year period (2009-2012).

Gill P, Wang LM, Bailey A, East JE, Leedham S, Chetty R. Gill P, et al. J Clin Pathol. 2013 Aug;66(8):655-8. doi: 10.1136/jclinpath-2013-201608. Epub 2013 Apr 10. J Clin Pathol. 2013. PMID: 23576460

10

Left-sided sessile serrated polyps/adenomas.

Chetty R, Wang LM, Gill P, East JE, Leedham S. Chetty R, et al. Hum Pathol. 2013 Sep;44(9):1959-60. doi: 10.1016/j.humpath.2013.05.017. Hum Pathol. 2013. PMID: 23969097 No abstract available.

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