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549 results

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Page 1
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
Jackman JK, Stockwell A, Choy DF, Xie MM, Lu P, Jia G, Li H, Abbas AR, Bronson PG, Lin WY, Chiu CPC, Maun HR, Roose-Girma M, Tam L, Zhang J, Modrusan Z, Graham RR, Behrens TW, White SR, Naureckas T, Ober C, Ferreira M, Sedlacek R, Wu J, Lee WP, Lazarus RA, Koerber JT, Arron JR, Yaspan BL, Yi T. Jackman JK, et al. Among authors: lee wp. J Allergy Clin Immunol. 2022 Oct;150(4):972-978.e7. doi: 10.1016/j.jaci.2022.03.033. Epub 2022 Apr 26. J Allergy Clin Immunol. 2022. PMID: 35487308 Free article.
Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling.
Jackman J, Chen Y, Huang A, Moffat B, Scheer JM, Leong SR, Lee WP, Zhang J, Sharma N, Lu Y, Iyer S, Shields RL, Chiang N, Bauer MC, Wadley D, Roose-Girma M, Vandlen R, Yansura DG, Wu Y, Wu LC. Jackman J, et al. Among authors: lee wp. J Biol Chem. 2010 Jul 2;285(27):20850-9. doi: 10.1074/jbc.M110.113910. Epub 2010 May 5. J Biol Chem. 2010. PMID: 20444694 Free PMC article.
Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.
Brightbill HD, Jeet S, Lin Z, Yan D, Zhou M, Tan M, Nguyen A, Yeh S, Delarosa D, Leong SR, Wong T, Chen Y, Ultsch M, Luis E, Ramani SR, Jackman J, Gonzalez L, Dennis MS, Chuntharapai A, DeForge L, Meng YG, Xu M, Eigenbrot C, Lee WP, Refino CJ, Balazs M, Wu LC. Brightbill HD, et al. Among authors: lee wp. J Clin Invest. 2010 Jun;120(6):2218-29. doi: 10.1172/JCI40141. Epub 2010 May 10. J Clin Invest. 2010. PMID: 20458139 Free PMC article.
Non-canonical inflammasome activation targets caspase-11.
Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, Zhang J, Lee WP, Roose-Girma M, Dixit VM. Kayagaki N, et al. Among authors: lee wp. Nature. 2011 Oct 16;479(7371):117-21. doi: 10.1038/nature10558. Nature. 2011. PMID: 22002608
Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1.
Spooner CJ, Lesch J, Yan D, Khan AA, Abbas A, Ramirez-Carrozzi V, Zhou M, Soriano R, Eastham-Anderson J, Diehl L, Lee WP, Modrusan Z, Pappu R, Xu M, DeVoss J, Singh H. Spooner CJ, et al. Among authors: lee wp. Nat Immunol. 2013 Dec;14(12):1229-36. doi: 10.1038/ni.2743. Epub 2013 Oct 20. Nat Immunol. 2013. PMID: 24141388
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM. Kayagaki N, et al. Among authors: lee wp, lee bl. Nature. 2015 Oct 29;526(7575):666-71. doi: 10.1038/nature15541. Epub 2015 Sep 16. Nature. 2015. PMID: 26375259
Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
Sun Y, Peng I, Webster JD, Suto E, Lesch J, Wu X, Senger K, Francis G, Barrett K, Collier JL, Burch JD, Zhou M, Chen Y, Chan C, Eastham-Anderson J, Ngu H, Li O, Staton T, Havnar C, Jaochico A, Jackman J, Jeet S, Riol-Blanco L, Wu LC, Choy DF, Arron JR, McKenzie BS, Ghilardi N, Ismaili MH, Pei Z, DeVoss J, Austin CD, Lee WP, Zarrin AA. Sun Y, et al. Among authors: lee wp. Sci Signal. 2015 Dec 1;8(405):ra122. doi: 10.1126/scisignal.aab0949. Sci Signal. 2015. PMID: 26628680
Depletion of major pathogenic cells in asthma by targeting CRTh2.
Huang T, Hazen M, Shang Y, Zhou M, Wu X, Yan D, Lin Z, Solon M, Luis E, Ngu H, Shi Y, Katewa A, Choy DF, Ramamoorthi N, Castellanos ER, Balazs M, Xu M, Lee WP, Matsumoto ML, Payandeh J, Arron JR, Hongo JA, Wang J, Hötzel I, Austin CD, Reif K. Huang T, et al. Among authors: lee wp. JCI Insight. 2016 May 19;1(7):e86689. doi: 10.1172/jci.insight.86689. JCI Insight. 2016. PMID: 27699264 Free PMC article.
549 results