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iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti-PD-1 therapy.
Cichocki F, Bjordahl R, Gaidarova S, Mahmood S, Abujarour R, Wang H, Tuininga K, Felices M, Davis ZB, Bendzick L, Clarke R, Stokely L, Rogers P, Ge M, Robinson M, Rezner B, Robbins DL, Lee TT, Kaufman DS, Blazar BR, Valamehr B, Miller JS. Cichocki F, et al. Among authors: lee tt. Sci Transl Med. 2020 Nov 4;12(568):eaaz5618. doi: 10.1126/scitranslmed.aaz5618. Sci Transl Med. 2020. PMID: 33148626 Free PMC article.
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy.
Woan KV, Kim H, Bjordahl R, Davis ZB, Gaidarova S, Goulding J, Hancock B, Mahmood S, Abujarour R, Wang H, Tuininga K, Zhang B, Wu CY, Kodal B, Khaw M, Bendzick L, Rogers P, Ge MQ, Bonello G, Meza M, Felices M, Huffman J, Dailey T, Lee TT, Walcheck B, Malmberg KJ, Blazar BR, Bryceson YT, Valamehr B, Miller JS, Cichocki F. Woan KV, et al. Among authors: lee tt. Cell Stem Cell. 2021 Dec 2;28(12):2062-2075.e5. doi: 10.1016/j.stem.2021.08.013. Epub 2021 Sep 14. Cell Stem Cell. 2021. PMID: 34525347 Free PMC article.
Dual antigen-targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia.
Cichocki F, Goodridge JP, Bjordahl R, Mahmood S, Davis ZB, Gaidarova S, Abujarour R, Groff B, Witty A, Wang H, Tuininga K, Kodal B, Felices M, Bonello G, Huffman J, Dailey T, Lee TT, Walcheck B, Valamehr B, Miller JS. Cichocki F, et al. Among authors: lee tt. Blood. 2022 Dec 8;140(23):2451-2462. doi: 10.1182/blood.2021015184. Blood. 2022. PMID: 35917442 Free PMC article.
Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells.
van der Stegen SJC, Lindenbergh PL, Petrovic RM, Xie H, Diop MP, Alexeeva V, Shi Y, Mansilla-Soto J, Hamieh M, Eyquem J, Cabriolu A, Wang X, Abujarour R, Lee T, Clarke R, Valamehr B, Themeli M, Riviere I, Sadelain M. van der Stegen SJC, et al. Nat Biomed Eng. 2022 Nov;6(11):1284-1297. doi: 10.1038/s41551-022-00915-0. Epub 2022 Aug 8. Nat Biomed Eng. 2022. PMID: 35941192 Free PMC article.
Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki F, Bjordahl R, Goodridge JP, Mahmood S, Gaidarova S, Abujarour R, Davis ZB, Merino A, Tuininga K, Wang H, Kumar A, Groff B, Witty A, Bonello G, Huffman J, Dailey T, Lee TT, Malmberg KJ, Walcheck B, Höpken U, Rehm A, Valamehr B, Miller JS. Cichocki F, et al. Among authors: lee tt. Nat Commun. 2022 Nov 29;13(1):7341. doi: 10.1038/s41467-022-35127-2. Nat Commun. 2022. PMID: 36446823 Free PMC article.
A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors.
Goulding J, Yeh WI, Hancock B, Blum R, Xu T, Yang BH, Chang CW, Groff B, Avramis E, Pribadi M, Pan Y, Chu HY, Sikaroodi S, Fong L, Brookhouser N, Dailey T, Meza M, Denholtz M, Diaz E, Martin J, Szabo P, Cooley S, Ferrari de Andrade L, Lee TT, Bjordahl R, Wucherpfennig KW, Valamehr B. Goulding J, et al. Among authors: lee tt. Med. 2023 Jul 14;4(7):457-477.e8. doi: 10.1016/j.medj.2023.04.004. Epub 2023 May 11. Med. 2023. PMID: 37172578
495 results