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O-antigen-deficient, live, attenuated Salmonella typhimurium confers efficient uptake, reduced cytotoxicity, and rapid clearance in chicken macrophages and lymphoid organs and induces significantly high protective immune responses that protect chickens against Salmonella infection.
Senevirathne A, Hewawaduge C, Park S, Park JY, Kirthika P, Lee JH. Senevirathne A, et al. Among authors: lee jh. Dev Comp Immunol. 2020 Oct;111:103745. doi: 10.1016/j.dci.2020.103745. Epub 2020 May 26. Dev Comp Immunol. 2020. PMID: 32470560
Deletion of the lon gene augments expression of Salmonella Pathogenicity Island (SPI)-1 and metal ion uptake genes leading to the accumulation of bactericidal hydroxyl radicals and host pro-inflammatory cytokine-mediated rapid intracellular clearance.
Kirthika P, Senevirathne A, Jawalagatti V, Park S, Lee JH. Kirthika P, et al. Among authors: lee jh. Gut Microbes. 2020 Nov 1;11(6):1695-1712. doi: 10.1080/19490976.2020.1777923. Epub 2020 Jun 21. Gut Microbes. 2020. PMID: 32567462 Free PMC article.
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