Lee J - Search Results

1

Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.

Malwal SR, Mazurek B, Ko J, Xie P, Barnes C, Varvitsiotis C, Zimmerman MD, Olatunji S, Lee J, Xie M, Sarathy J, Caffrey M, Strynadka NCJ, Dartois V, Dick T, Lee BNR, Russell DG, Oldfield E. Malwal SR, et al. Among authors: lee j, lee bnr. J Med Chem. 2023 Jun 8;66(11):7553-7569. doi: 10.1021/acs.jmedchem.3c00398. Epub 2023 May 26. J Med Chem. 2023. PMID: 37235809 Free PMC article.

2

Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site.

Lee J, Worrall LJ, Vuckovic M, Rosell FI, Gentile F, Ton AT, Caveney NA, Ban F, Cherkasov A, Paetzel M, Strynadka NCJ. Lee J, et al. Nat Commun. 2020 Nov 18;11(1):5877. doi: 10.1038/s41467-020-19662-4. Nat Commun. 2020. PMID: 33208735 Free PMC article.

3

X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation.

Lee J, Kenward C, Worrall LJ, Vuckovic M, Gentile F, Ton AT, Ng M, Cherkasov A, Strynadka NCJ, Paetzel M. Lee J, et al. Nat Commun. 2022 Sep 3;13(1):5196. doi: 10.1038/s41467-022-32854-4. Nat Commun. 2022. PMID: 36057636 Free PMC article.

4

Large-Scale Virtual Screening for the Discovery of SARS-CoV-2 Papain-like Protease (PLpro) Non-covalent Inhibitors.

Garland O, Ton AT, Moradi S, Smith JR, Kovacic S, Ng K, Pandey M, Ban F, Lee J, Vuckovic M, Worrall LJ, Young RN, Pantophlet R, Strynadka NCJ, Cherkasov A. Garland O, et al. Among authors: lee j. J Chem Inf Model. 2023 Apr 10;63(7):2158-2169. doi: 10.1021/acs.jcim.2c01641. Epub 2023 Mar 17. J Chem Inf Model. 2023. PMID: 36930801

5

A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.

Pérez-Vargas J, Worrall LJ, Olmstead AD, Ton AT, Lee J, Villanueva I, Thompson CAH, Dudek S, Ennis S, Smith JR, Shapira T, De Guzman J, Gang S, Ban F, Vuckovic M, Bielecki M, Kovacic S, Kenward C, Hong CY, Gordon DG, Levett PN, Krajden M, Leduc R, Boudreault PL, Niikura M, Paetzel M, Young RN, Cherkasov A, Strynadka NCJ, Jean F. Pérez-Vargas J, et al. Among authors: lee j. Emerg Microbes Infect. 2023 Dec;12(2):2246594. doi: 10.1080/22221751.2023.2246594. Emerg Microbes Infect. 2023. PMID: 37555275 Free PMC article.

6

Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1.

Bon CG, Grigg JC, Lee J, Robb CS, Caveney NA, Eltis LD, Strynadka NCJ. Bon CG, et al. Among authors: lee j. J Struct Biol. 2024 Mar 26;216(2):108086. doi: 10.1016/j.jsb.2024.108086. Online ahead of print. J Struct Biol. 2024. PMID: 38527711 Free article.

7

Brefeldin A causes a defect in secretion in Saccharomyces cerevisiae.

Vogel JP, Lee JN, Kirsch DR, Rose MD, Sztul ES. Vogel JP, et al. Among authors: lee jn. J Biol Chem. 1993 Feb 15;268(5):3040-3. J Biol Chem. 1993. PMID: 8428980 Free article.

8

Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold.

Lee J, Johnson J, Ding Z, Paetzel M, Cornell RB. Lee J, et al. J Biol Chem. 2009 Nov 27;284(48):33535-48. doi: 10.1074/jbc.M109.053363. Epub 2009 Sep 25. J Biol Chem. 2009. PMID: 19783652 Free PMC article.

9

Structural basis for autoinhibition of CTP:phosphocholine cytidylyltransferase (CCT), the regulatory enzyme in phosphatidylcholine synthesis, by its membrane-binding amphipathic helix.

Lee J, Taneva SG, Holland BW, Tieleman DP, Cornell RB. Lee J, et al. J Biol Chem. 2014 Jan 17;289(3):1742-55. doi: 10.1074/jbc.M113.526970. Epub 2013 Nov 25. J Biol Chem. 2014. PMID: 24275660 Free PMC article.

10

Disease-linked mutations in the phosphatidylcholine regulatory enzyme CCTα impair enzymatic activity and fold stability.

Cornell RB, Taneva SG, Dennis MK, Tse R, Dhillon RK, Lee J. Cornell RB, et al. Among authors: lee j. J Biol Chem. 2019 Feb 1;294(5):1490-1501. doi: 10.1074/jbc.RA118.006457. Epub 2018 Dec 17. J Biol Chem. 2019. PMID: 30559292 Free PMC article.

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