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The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells.
Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. Bertin S, et al. Among authors: lee j. Nat Immunol. 2014 Nov;15(11):1055-1063. doi: 10.1038/ni.3009. Epub 2014 Oct 5. Nat Immunol. 2014. PMID: 25282159 Free PMC article.
Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis.
de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, Eckmann L, Stanford SM, Bottini N, Corr M, Raz E. de Jong PR, et al. Among authors: lee j. J Clin Invest. 2014 Sep;124(9):3793-806. doi: 10.1172/JCI72340. Epub 2014 Aug 1. J Clin Invest. 2014. PMID: 25083990 Free PMC article.
The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1.
Bertin S, Aoki-Nonaka Y, Lee J, de Jong PR, Kim P, Han T, Yu T, To K, Takahashi N, Boland BS, Chang JT, Ho SB, Herdman S, Corr M, Franco A, Sharma S, Dong H, Akopian AN, Raz E. Bertin S, et al. Among authors: lee j. Gut. 2017 Sep;66(9):1584-1596. doi: 10.1136/gutjnl-2015-310710. Epub 2016 Jun 20. Gut. 2017. PMID: 27325418 Free PMC article.
PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells.
Chinn AM, Salmerón C, Lee J, Sriram K, Raz E, Insel PA. Chinn AM, et al. Among authors: lee j. Front Pharmacol. 2022 Mar 21;13:833832. doi: 10.3389/fphar.2022.833832. eCollection 2022. Front Pharmacol. 2022. PMID: 35387344 Free PMC article.
Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease.
Zeng S, Rosati E, Saggau C, Messner B, Chu H, Duan Y, Hartmann P, Wang Y, Ma S, Huang WJM, Lee J, Lee SM, Carvalho-Gontijo R, Zhang V, Hoffmann JP, Kolls JK, Raz E, Brenner DA, Kisseleva T, LeibundGut-Landmann S, Bacher P, Stärkel P, Schnabl B. Zeng S, et al. Among authors: lee j, lee sm. Cell Host Microbe. 2023 Mar 8;31(3):389-404.e7. doi: 10.1016/j.chom.2023.02.001. Cell Host Microbe. 2023. PMID: 36893735 Free PMC article.
ANT2 drives proinflammatory macrophage activation in obesity.
Moon JS, da Cunha FF, Huh JY, Andreyev AY, Lee J, Mahata SK, Reis FC, Nasamran CA, Lee YS. Moon JS, et al. Among authors: lee j, lee ys. JCI Insight. 2021 Oct 22;6(20):e147033. doi: 10.1172/jci.insight.147033. JCI Insight. 2021. PMID: 34676827 Free PMC article.
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