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Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines (KRCA-0008) as potent and selective ALK inhibitors for anticancer treatment.
Park CH, Choe H, Jang IY, Kwon SY, Latif M, Lee HK, Lee HJ, Yang EH, Yun JI, Chae CH, Cho SY, Choi SU, Ha JD, Jung H, Kim HR, Kim P, Lee CO, Yun CS, Lee K. Park CH, et al. Among authors: lee k, lee co, lee hk, lee hj. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6192-6. doi: 10.1016/j.bmcl.2013.08.090. Epub 2013 Sep 4. Bioorg Med Chem Lett. 2013. PMID: 24095090
Development of potent ALK inhibitor and its molecular inhibitory mechanism against NSCLC harboring EML4-ALK proteins.
Kang CH, Yun JI, Lee K, Lee CO, Lee HK, Yun CS, Hwang JY, Cho SY, Jung H, Kim P, Ha JD, Jeon JH, Choi SU, Jeong HG, Kim HR, Park CH. Kang CH, et al. Among authors: lee k, lee co, lee hk. Biochem Biophys Res Commun. 2015 Aug 28;464(3):762-7. doi: 10.1016/j.bbrc.2015.07.027. Epub 2015 Jul 10. Biochem Biophys Res Commun. 2015. PMID: 26168728
Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R.
Mathi GR, Kang CH, Lee HK, Achary R, Lee HY, Lee JY, Ha JD, Ahn S, Park CH, Lee CO, Hwang JY, Yun CS, Jung HJ, Cho SY, Kim HR, Kim P. Mathi GR, et al. Among authors: lee co, lee jy, lee hy, lee hk. Eur J Med Chem. 2017 Jan 27;126:536-549. doi: 10.1016/j.ejmech.2016.11.046. Epub 2016 Nov 24. Eur J Med Chem. 2017. PMID: 27915169
4,060 results