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Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine.
Hulce KR, Jaishankar P, Lee GM, Bohn MF, Connelly EJ, Wucherer K, Ongpipattanakul C, Volk RF, Chuo SW, Arkin MR, Renslo AR, Craik CS. Hulce KR, et al. Among authors: lee gm. Cell Chem Biol. 2022 May 19;29(5):785-798.e19. doi: 10.1016/j.chembiol.2022.03.007. Epub 2022 Mar 31. Cell Chem Biol. 2022. PMID: 35364007 Free PMC article.
Inhibition of a viral enzyme by a small-molecule dimer disruptor.
Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS. Shahian T, et al. Among authors: lee gm. Nat Chem Biol. 2009 Sep;5(9):640-6. doi: 10.1038/nchembio.192. Epub 2009 Jul 26. Nat Chem Biol. 2009. PMID: 19633659 Free PMC article.
Broad-spectrum allosteric inhibition of herpesvirus proteases.
Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. Gable JE, et al. Among authors: lee gm. Biochemistry. 2014 Jul 22;53(28):4648-60. doi: 10.1021/bi5003234. Epub 2014 Jul 11. Biochemistry. 2014. PMID: 24977643 Free PMC article.
Trapping moving targets with small molecules.
Lee GM, Craik CS. Lee GM, et al. Science. 2009 Apr 10;324(5924):213-5. doi: 10.1126/science.1169378. Science. 2009. PMID: 19359579 Free PMC article.
672 results