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Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes.
Ledsgaard L, Wade J, Jenkins TP, Boddum K, Oganesyan I, Harrison JA, Villar P, Leah RA, Zenobi R, Schoffelen S, Voldborg B, Ljungars A, McCafferty J, Lomonte B, Gutiérrez JM, Laustsen AH, Karatt-Vellatt A. Ledsgaard L, et al. Nat Commun. 2023 Feb 8;14(1):682. doi: 10.1038/s41467-023-36393-4. Nat Commun. 2023. PMID: 36755049 Free PMC article.
Pros and cons of different therapeutic antibody formats for recombinant antivenom development.
Laustsen AH, María Gutiérrez J, Knudsen C, Johansen KH, Bermúdez-Méndez E, Cerni FA, Jürgensen JA, Ledsgaard L, Martos-Esteban A, Øhlenschlæger M, Pus U, Andersen MR, Lomonte B, Engmark M, Pucca MB. Laustsen AH, et al. Among authors: ledsgaard l. Toxicon. 2018 May;146:151-175. doi: 10.1016/j.toxicon.2018.03.004. Epub 2018 Mar 10. Toxicon. 2018. PMID: 29534892 Free article. Review.
Basics of Antibody Phage Display Technology.
Ledsgaard L, Kilstrup M, Karatt-Vellatt A, McCafferty J, Laustsen AH. Ledsgaard L, et al. Toxins (Basel). 2018 Jun 9;10(6):236. doi: 10.3390/toxins10060236. Toxins (Basel). 2018. PMID: 29890762 Free PMC article. Review.
Antibody Cross-Reactivity in Antivenom Research.
Ledsgaard L, Jenkins TP, Davidsen K, Krause KE, Martos-Esteban A, Engmark M, Rørdam Andersen M, Lund O, Laustsen AH. Ledsgaard L, et al. Toxins (Basel). 2018 Sep 27;10(10):393. doi: 10.3390/toxins10100393. Toxins (Basel). 2018. PMID: 30261694 Free PMC article. Review.
History of Envenoming Therapy and Current Perspectives.
Pucca MB, Cerni FA, Janke R, Bermúdez-Méndez E, Ledsgaard L, Barbosa JE, Laustsen AH. Pucca MB, et al. Among authors: ledsgaard l. Front Immunol. 2019 Jul 10;10:1598. doi: 10.3389/fimmu.2019.01598. eCollection 2019. Front Immunol. 2019. PMID: 31354735 Free PMC article. Review.
Unity Makes Strength: Exploring Intraspecies and Interspecies Toxin Synergism between Phospholipases A2 and Cytotoxins.
Pucca MB, Ahmadi S, Cerni FA, Ledsgaard L, Sørensen CV, McGeoghan FTS, Stewart T, Schoof E, Lomonte B, Auf dem Keller U, Arantes EC, Çalışkan F, Laustsen AH. Pucca MB, et al. Among authors: ledsgaard l. Front Pharmacol. 2020 May 7;11:611. doi: 10.3389/fphar.2020.00611. eCollection 2020. Front Pharmacol. 2020. PMID: 32457615 Free PMC article.
Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.
Bullen G, Galson JD, Hall G, Villar P, Moreels L, Ledsgaard L, Mattiuzzo G, Bentley EM, Masters EW, Tang D, Millett S, Tongue D, Brown R, Diamantopoulos I, Parthiban K, Tebbutt C, Leah R, Chaitanya K, Ergueta-Carballo S, Pazeraitis D, Surade SB, Ashiru O, Crippa L, Cowan R, Bowler MW, Campbell JI, Lee WJ, Carr MD, Matthews D, Pfeffer P, Hufton SE, Sawmynaden K, Osbourn J, McCafferty J, Karatt-Vellatt A. Bullen G, et al. Among authors: ledsgaard l. Front Immunol. 2021 Jun 15;12:678570. doi: 10.3389/fimmu.2021.678570. eCollection 2021. Front Immunol. 2021. PMID: 34211469 Free PMC article.
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