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Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H3 receptor antagonist/inverse agonist.
Eur J Pharmacol. 2022 Feb 5;916:174621. doi: 10.1016/j.ejphar.2021.174621. Epub 2021 Dec 26.
Eur J Pharmacol. 2022.
PMID: 34965389
Discovery of novel steroidal histamine H3 receptor antagonists/inverse agonists.
Ledneczki I, Tapolcsányi P, Gábor E, Éles J, Greiner I, Schmidt É, Némethy Z, Kedves RS, Balázs O, Román V, Lévay G, Mahó S.
Ledneczki I, et al.
Bioorg Med Chem Lett. 2017 Oct 1;27(19):4525-4530. doi: 10.1016/j.bmcl.2017.08.060. Epub 2017 Sep 1.
Bioorg Med Chem Lett. 2017.
PMID: 28888822
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Discovery of novel steroidal histamine H3 receptor antagonists/inverse agonists. Part 2. Versatile steroidal carboxamide derivatives.
Ledneczki I, Némethy Z, Tapolcsányi P, Éles J, Greiner I, Gábor E, Varga B, Balázs O, Román V, Lévay G, Mahó S.
Ledneczki I, et al.
Bioorg Med Chem Lett. 2019 Oct 15;29(20):126643. doi: 10.1016/j.bmcl.2019.126643. Epub 2019 Aug 28.
Bioorg Med Chem Lett. 2019.
PMID: 31492518
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Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach.
Ledneczki I, Tapolcsányi P, Gábor E, Visegrády A, Vass M, Éles J, Holm P, Horváth A, Pocsai A, Mahó S, Greiner I, Krámos B, Béni Z, Kóti J, Káncz AE, Thán M, Kolok S, Laszy J, Balázs O, Bugovits G, Nagy J, Vastag M, Szájli Á, Bozó É, Lévay G, Lendvai B, Némethy Z.
Ledneczki I, et al.
Eur J Med Chem. 2021 Mar 15;214:113189. doi: 10.1016/j.ejmech.2021.113189. Epub 2021 Jan 14.
Eur J Med Chem. 2021.
PMID: 33540354
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HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Ledneczki I, Horváth A, Tapolcsányi P, Éles J, Molnár KD, Vágó I, Visegrády A, Kiss L, Szigetvári Á, Kóti J, Krámos B, Mahó S, Holm P, Kolok S, Fodor L, Thán M, Kostyalik D, Balázs O, Vastag M, Greiner I, Lévay G, Lendvai B, Némethy Z.
Ledneczki I, et al.
Eur J Med Chem. 2021 Oct 15;222:113560. doi: 10.1016/j.ejmech.2021.113560. Epub 2021 May 29.
Eur J Med Chem. 2021.
PMID: 34111828
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Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560).
Ledneczki I, Némethy Z, Molnár KD, Tapolcsányi P, Ilkei V, Vágó I, Kolok S, Thán M, Laszy J, Balázs O, Krámos B, Szigetvári Á, Bata I, Makó A, Visegrády A, Fodor L, Vastag M, Lévay G, Lendvai B, Greiner I, Éles J.
Ledneczki I, et al.
J Med Chem. 2023 Dec 14;66(23):16276-16302. doi: 10.1021/acs.jmedchem.3c01635. Epub 2023 Nov 21.
J Med Chem. 2023.
PMID: 37989278
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Discovery of Novel Steroid-Based Histamine H3 Receptor Antagonists/Inverse Agonists.
Ledneczki I, Tapolcsányi P, Gábor E, Éles J, Barabás J, Béni Z, Varga B, Balázs O, Román V, Fodor L, Szikra J, Vastag M, Lévay G, Schmidt É, Lendvai B, Greiner I, Kiss B, Némethy Z, Mahó S.
Ledneczki I, et al.
J Med Chem. 2024 Mar 14;67(5):3643-3667. doi: 10.1021/acs.jmedchem.3c02117. Epub 2024 Feb 23.
J Med Chem. 2024.
PMID: 38393759
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Direct electrophilic monofluoromethylation.
Prakash GK, Ledneczki I, Chacko S, Olah GA.
Prakash GK, et al. Among authors: ledneczki i.
Org Lett. 2008 Feb 21;10(4):557-60. doi: 10.1021/ol702500u. Epub 2008 Jan 17.
Org Lett. 2008.
PMID: 18198880
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