Leder L - Search Results

1

Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery.

Ottl J, Leder L, Schaefer JV, Dumelin CE. Ottl J, et al. Among authors: leder l. Molecules. 2019 Apr 25;24(8):1629. doi: 10.3390/molecules24081629. Molecules. 2019. PMID: 31027189 Free PMC article. Review.

2

Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2.

Tirat A, Schilb A, Riou V, Leder L, Gerhartz B, Zimmermann J, Worpenberg S, Eidhoff U, Freuler F, Stettler T, Mayr L, Ottl J, Leuenberger B, Filipuzzi I. Tirat A, et al. Among authors: leder l. Anal Biochem. 2005 Aug 15;343(2):244-55. doi: 10.1016/j.ab.2005.04.023. Anal Biochem. 2005. PMID: 15963938

3

Readout technologies for highly miniaturized kinase assays applicable to high-throughput screening in a 1536-well format.

Klumpp M, Boettcher A, Becker D, Meder G, Blank J, Leder L, Forstner M, Ottl J, Mayr LM. Klumpp M, et al. Among authors: leder l. J Biomol Screen. 2006 Sep;11(6):617-33. doi: 10.1177/1087057106288444. Epub 2006 Jun 7. J Biomol Screen. 2006. PMID: 16760365

4

Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches.

Vulpetti A, Rondeau JM, Bellance MH, Blank J, Boesch R, Boettcher A, Bornancin F, Buhr S, Connor LE, Dumelin CE, Esser O, Hediger M, Hintermann S, Hommel U, Koch E, Lapointe G, Leder L, Lehmann S, Lehr P, Meier P, Muller L, Ostermeier D, Ramage P, Schiebel-Haddad S, Smith AB, Stojanovic A, Velcicky J, Yamamoto R, Hurth K. Vulpetti A, et al. Among authors: leder l. J Med Chem. 2024 May 10. doi: 10.1021/acs.jmedchem.4c00240. Online ahead of print. J Med Chem. 2024. PMID: 38728572

5

HDL-like discs for assaying membrane proteins in drug discovery.

Fiez-Vandal C, Leder L, Freuler F, Sykes D, Charlton SJ, Siehler S, Schopfer U, Duckely M. Fiez-Vandal C, et al. Among authors: leder l. Biophys Chem. 2012 May;165-166:56-61. doi: 10.1016/j.bpc.2012.03.005. Epub 2012 Mar 19. Biophys Chem. 2012. PMID: 22542136

6

Site-specific protein labeling in the pharmaceutical industry: experiences from novartis drug discovery.

Leder L. Leder L. Methods Mol Biol. 2015;1266:7-27. doi: 10.1007/978-1-4939-2272-7_2. Methods Mol Biol. 2015. PMID: 25560065 Review.

7

New methods for efficient protein production in drug discovery.

Leder L, Freuler F, Forstner M, Mayr LM. Leder L, et al. Curr Opin Drug Discov Devel. 2007 Mar;10(2):193-202. Curr Opin Drug Discov Devel. 2007. PMID: 17436555 Review.

8

The structure of Ca2+ sensor Case16 reveals the mechanism of reaction to low Ca2+ concentrations.

Leder L, Stark W, Freuler F, Marsh M, Meyerhofer M, Stettler T, Mayr LM, Britanova OV, Strukova LA, Chudakov DM, Souslova EA. Leder L, et al. Sensors (Basel). 2010;10(9):8143-60. doi: 10.3390/s100908143. Epub 2010 Aug 30. Sensors (Basel). 2010. PMID: 22163646 Free PMC article.

9

Optimization of protein expression systems for modern drug discovery.

Forstner M, Leder L, Mayr LM. Forstner M, et al. Among authors: leder l. Expert Rev Proteomics. 2007 Feb;4(1):67-78. doi: 10.1586/14789450.4.1.67. Expert Rev Proteomics. 2007. PMID: 17288516 Review.

10

X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome.

Kallen J, Bergsdorf C, Arnaud B, Bernhard M, Brichet M, Cobos-Correa A, Elhajouji A, Freuler F, Galimberti I, Guibourdenche C, Haenni S, Holzinger S, Hunziker J, Izaac A, Kaufmann M, Leder L, Martus HJ, von Matt P, Polyakov V, Roethlisberger P, Roma G, Stiefl N, Uteng M, Lerchner A. Kallen J, et al. Among authors: leder l. ChemMedChem. 2018 Sep 19;13(18):1997-2007. doi: 10.1002/cmdc.201800344. Epub 2018 Aug 16. ChemMedChem. 2018. PMID: 29985556

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