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Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.
Fischer J, Walter C, Tönges A, Aleth H, Jordão MJC, Leddin M, Gröning V, Erdmann T, Lenz G, Roth J, Vogl T, Prinz M, Dugas M, Jacobsen ID, Rosenbauer F. Fischer J, et al. Among authors: leddin m. Nat Immunol. 2019 May;20(5):546-558. doi: 10.1038/s41590-019-0343-z. Epub 2019 Mar 25. Nat Immunol. 2019. PMID: 30911105
Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells.
Leddin M, Perrod C, Hoogenkamp M, Ghani S, Assi S, Heinz S, Wilson NK, Follows G, Schönheit J, Vockentanz L, Mosammam AM, Chen W, Tenen DG, Westhead DR, Göttgens B, Bonifer C, Rosenbauer F. Leddin M, et al. Blood. 2011 Mar 10;117(10):2827-38. doi: 10.1182/blood-2010-08-302976. Epub 2011 Jan 14. Blood. 2011. PMID: 21239694 Free PMC article.
Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.
Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG. Staber PB, et al. Among authors: leddin m. Mol Cell. 2013 Mar 7;49(5):934-46. doi: 10.1016/j.molcel.2013.01.007. Epub 2013 Feb 8. Mol Cell. 2013. PMID: 23395001 Free PMC article.
Mesenchymal stromal cell characteristics vary depending on their origin.
Wegmeyer H, Bröske AM, Leddin M, Kuentzer K, Nisslbeck AK, Hupfeld J, Wiechmann K, Kuhlen J, von Schwerin C, Stein C, Knothe S, Funk J, Huss R, Neubauer M. Wegmeyer H, et al. Among authors: leddin m. Stem Cells Dev. 2013 Oct 1;22(19):2606-18. doi: 10.1089/scd.2013.0016. Epub 2013 Jun 22. Stem Cells Dev. 2013. PMID: 23676112 Free PMC article.
Patient listening on social media for patient-focused drug development: a synthesis of considerations from patients, industry and regulators.
Cimiano P, Collins B, De Vuono MC, Escudier T, Gottowik J, Hartung M, Leddin M, Neupane B, Rodriguez-Esteban R, Schmidt AL, Starke-Knäusel C, Voorhaar M, Wieckowski K. Cimiano P, et al. Among authors: leddin m. Front Med (Lausanne). 2024 Mar 6;11:1274688. doi: 10.3389/fmed.2024.1274688. eCollection 2024. Front Med (Lausanne). 2024. PMID: 38515987 Free PMC article.