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USP7 limits CDK1 activity throughout the cell cycle.
Galarreta A, Valledor P, Ubieto-Capella P, Lafarga V, Zarzuela E, Muñoz J, Malumbres M, Lecona E, Fernandez-Capetillo O. Galarreta A, et al. Among authors: lecona e. EMBO J. 2021 Jun 1;40(11):e99692. doi: 10.15252/embj.201899692. Epub 2021 Apr 15. EMBO J. 2021. PMID: 33856059 Free PMC article.
USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork.
Franz A, Valledor P, Ubieto-Capella P, Pilger D, Galarreta A, Lafarga V, Fernández-Llorente A, de la Vega-Barranco G, den Brave F, Hoppe T, Fernandez-Capetillo O, Lecona E. Franz A, et al. Among authors: lecona e. Cell Rep. 2021 Oct 12;37(2):109819. doi: 10.1016/j.celrep.2021.109819. Cell Rep. 2021. PMID: 34644576 Free PMC article.
USP7 is a SUMO deubiquitinase essential for DNA replication.
Lecona E, Rodriguez-Acebes S, Specks J, Lopez-Contreras AJ, Ruppen I, Murga M, Muñoz J, Mendez J, Fernandez-Capetillo O. Lecona E, et al. Nat Struct Mol Biol. 2016 Apr;23(4):270-7. doi: 10.1038/nsmb.3185. Epub 2016 Mar 7. Nat Struct Mol Biol. 2016. PMID: 26950370 Free PMC article.
Targeting ATR in cancer.
Lecona E, Fernandez-Capetillo O. Lecona E, et al. Nat Rev Cancer. 2018 Sep;18(9):586-595. doi: 10.1038/s41568-018-0034-3. Nat Rev Cancer. 2018. PMID: 29899559 Review.
Replication stress and cancer: it takes two to tango.
Lecona E, Fernández-Capetillo O. Lecona E, et al. Exp Cell Res. 2014 Nov 15;329(1):26-34. doi: 10.1016/j.yexcr.2014.09.019. Epub 2014 Sep 26. Exp Cell Res. 2014. PMID: 25257608 Free PMC article. Review.
NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.
Jacome A, Gutierrez-Martinez P, Schiavoni F, Tenaglia E, Martinez P, Rodríguez-Acebes S, Lecona E, Murga M, Méndez J, Blasco MA, Fernandez-Capetillo O. Jacome A, et al. Among authors: lecona e. EMBO J. 2015 Nov 3;34(21):2604-19. doi: 10.15252/embj.201591829. Epub 2015 Oct 6. EMBO J. 2015. PMID: 26443207 Free PMC article.
Efficacy of ATR inhibitors as single agents in Ewing sarcoma.
Nieto-Soler M, Morgado-Palacin I, Lafarga V, Lecona E, Murga M, Callen E, Azorin D, Alonso J, Lopez-Contreras AJ, Nussenzweig A, Fernandez-Capetillo O. Nieto-Soler M, et al. Among authors: lecona e. Oncotarget. 2016 Sep 13;7(37):58759-58767. doi: 10.18632/oncotarget.11643. Oncotarget. 2016. PMID: 27577084 Free PMC article.
36 results