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Engineered Production of Short-Chain Acyl-Coenzyme A Esters in Saccharomyces cerevisiae.
Krink-Koutsoubelis N, Loechner AC, Lechner A, Link H, Denby CM, Vögeli B, Erb TJ, Yuzawa S, Jakociunas T, Katz L, Jensen MK, Sourjik V, Keasling JD. Krink-Koutsoubelis N, et al. Among authors: lechner a. ACS Synth Biol. 2018 Apr 20;7(4):1105-1115. doi: 10.1021/acssynbio.7b00466. Epub 2018 Mar 12. ACS Synth Biol. 2018. PMID: 29498824
The Need for Integrated Approaches in Metabolic Engineering.
Lechner A, Brunk E, Keasling JD. Lechner A, et al. Cold Spring Harb Perspect Biol. 2016 Nov 1;8(11):a023903. doi: 10.1101/cshperspect.a023903. Cold Spring Harb Perspect Biol. 2016. PMID: 27527588 Free PMC article. Review.
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast.
Luo X, Reiter MA, d'Espaux L, Wong J, Denby CM, Lechner A, Zhang Y, Grzybowski AT, Harth S, Lin W, Lee H, Yu C, Shin J, Deng K, Benites VT, Wang G, Baidoo EEK, Chen Y, Dev I, Petzold CJ, Keasling JD. Luo X, et al. Among authors: lechner a. Nature. 2019 Mar;567(7746):123-126. doi: 10.1038/s41586-019-0978-9. Epub 2019 Feb 27. Nature. 2019. PMID: 30814733
Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase.
Englund E, Schmidt M, Nava AA, Lechner A, Deng K, Jocic R, Lin Y, Roberts J, Benites VT, Kakumanu R, Gin JW, Chen Y, Liu Y, Petzold CJ, Baidoo EEK, Northen TR, Adams PD, Katz L, Yuzawa S, Keasling JD. Englund E, et al. Among authors: lechner a. J Am Chem Soc. 2023 Apr 26;145(16):8822-8832. doi: 10.1021/jacs.2c11027. Epub 2023 Apr 14. J Am Chem Soc. 2023. PMID: 37057992 Free PMC article.
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.
Eustáquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore BS. Eustáquio AS, et al. Among authors: lechner a. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12295-300. doi: 10.1073/pnas.0901237106. Epub 2009 Jul 9. Proc Natl Acad Sci U S A. 2009. PMID: 19590008 Free PMC article.
358 results