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Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
Gout J, Perkhofer L, Morawe M, Arnold F, Ihle M, Biber S, Lange S, Roger E, Kraus JM, Stifter K, Hahn SA, Zamperone A, Engleitner T, Müller M, Walter K, Rodriguez-Aznar E, Sainz B Jr, Hermann PC, Hessmann E, Müller S, Azoitei N, Lechel A, Liebau S, Wagner M, Simeone DM, Kestler HA, Seufferlein T, Wiesmüller L, Rad R, Frappart PO, Kleger A. Gout J, et al. Among authors: lechel a. Gut. 2021 Apr;70(4):743-760. doi: 10.1136/gutjnl-2019-319970. Epub 2020 Sep 1. Gut. 2021. PMID: 32873698 Free PMC article.
Increased reprogramming capacity of mouse liver progenitor cells, compared with differentiated liver cells, requires the BAF complex.
Kleger A, Mahaddalkar PU, Katz SF, Lechel A, Joo JY, Loya K, Lin Q, Hartmann D, Liebau S, Kraus JM, Cantz T, Kestler HA, Zaehres H, Schöler H, Rudolph KL. Kleger A, et al. Among authors: lechel a. Gastroenterology. 2012 Apr;142(4):907-17. doi: 10.1053/j.gastro.2012.01.004. Epub 2012 Jan 12. Gastroenterology. 2012. PMID: 22245845
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.
Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL. Wang J, et al. Among authors: lechel a. Cell. 2012 Mar 2;148(5):1001-14. doi: 10.1016/j.cell.2012.01.040. Cell. 2012. PMID: 22385964 Free article.
Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition.
Russell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld FM, Hessmann E, Gaedcke J, Güthle M, Zenke M, Hartmann D, von Figura G, Weissinger SE, Rudolph KL, Möller P, Lennerz JK, Seufferlein T, Wagner M, Kleger A. Russell R, et al. Among authors: lechel a. Nat Commun. 2015 Jul 29;6:7677. doi: 10.1038/ncomms8677. Nat Commun. 2015. PMID: 26220524 Free PMC article.
A Dynamic Role of TBX3 in the Pluripotency Circuitry.
Russell R, Ilg M, Lin Q, Wu G, Lechel A, Bergmann W, Eiseler T, Linta L, Kumar P P, Klingenstein M, Adachi K, Hohwieler M, Sakk O, Raab S, Moon A, Zenke M, Seufferlein T, Schöler HR, Illing A, Liebau S, Kleger A. Russell R, et al. Among authors: lechel a. Stem Cell Reports. 2015 Dec 8;5(6):1155-1170. doi: 10.1016/j.stemcr.2015.11.003. Stem Cell Reports. 2015. PMID: 26651606 Free PMC article.
69 results