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Fibroblast activation in response to TGFβ1 is modulated by co-culture with endothelial cells in a vascular organ-on-chip platform.
Luu RJ, Hoefler BC, Gard AL, Ritenour CR, Rogers MT, Kim ES, Coppeta JR, Cain BP, Isenberg BC, Azizgolshani H, Fajardo-Ramirez OR, García-Cardeña G, Lech MP, Tomlinson L, Charest JL, Williams C. Luu RJ, et al. Among authors: lech mp. Front Mol Biosci. 2023 Jul 28;10:1160851. doi: 10.3389/fmolb.2023.1160851. eCollection 2023. Front Mol Biosci. 2023. PMID: 37577751 Free PMC article.
High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows.
Azizgolshani H, Coppeta JR, Vedula EM, Marr EE, Cain BP, Luu RJ, Lech MP, Kann SH, Mulhern TJ, Tandon V, Tan K, Haroutunian NJ, Keegan P, Rogers M, Gard AL, Baldwin KB, de Souza JC, Hoefler BC, Bale SS, Kratchman LB, Zorn A, Patterson A, Kim ES, Petrie TA, Wiellette EL, Williams C, Isenberg BC, Charest JL. Azizgolshani H, et al. Among authors: lech mp. Lab Chip. 2021 Apr 20;21(8):1454-1474. doi: 10.1039/d1lc00067e. Lab Chip. 2021. PMID: 33881130
A protein kinase C α and β inhibitor blunts hyperphagia to halt renal function decline and reduces adiposity in a rat model of obesity-driven type 2 diabetes.
Wang J, Casimiro-Garcia A, Johnson BG, Duffen J, Cain M, Savary L, Wang S, Nambiar P, Lech M, Zhao S, Xi L, Zhan Y, Olson J, Stejskal JA, Lin H, Zhang B, Martinez RV, Masek-Hammerman K, Schlerman FJ, Dower K. Wang J, et al. Sci Rep. 2023 Oct 7;13(1):16919. doi: 10.1038/s41598-023-43759-7. Sci Rep. 2023. PMID: 37805649 Free PMC article.
High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy.
Dower K, Zhao S, Schlerman FJ, Savary L, Campanholle G, Johnson BG, Xi L, Nguyen V, Zhan Y, Lech MP, Wang J, Nie Q, Karsdal MA, Genovese F, Boucher G, Brown TP, Zhang B, Homer BL, Martinez RV. Dower K, et al. Among authors: lech mp. PLoS One. 2017 Jul 26;12(7):e0181861. doi: 10.1371/journal.pone.0181861. eCollection 2017. PLoS One. 2017. PMID: 28746409 Free PMC article.
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation.
Fabre T, Barron AMS, Christensen SM, Asano S, Bound K, Lech MP, Wadsworth MH 2nd, Chen X, Wang C, Wang J, McMahon J, Schlerman F, White A, Kravarik KM, Fisher AJ, Borthwick LA, Hart KM, Henderson NC, Wynn TA, Dower K. Fabre T, et al. Among authors: lech mp. Sci Immunol. 2023 Apr 14;8(82):eadd8945. doi: 10.1126/sciimmunol.add8945. Epub 2023 Apr 7. Sci Immunol. 2023. PMID: 37027478
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems.
Ross TT, Crowley C, Kelly KL, Rinaldi A, Beebe DA, Lech MP, Martinez RV, Carvajal-Gonzalez S, Boucher M, Hirenallur-Shanthappa D, Morin J, Opsahl AC, Vargas SR, Bence KK, Pfefferkorn JA, Esler WP. Ross TT, et al. Among authors: lech mp. Cell Mol Gastroenterol Hepatol. 2020;10(4):829-851. doi: 10.1016/j.jcmgh.2020.06.001. Epub 2020 Jun 9. Cell Mol Gastroenterol Hepatol. 2020. PMID: 32526482 Free PMC article.