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Clotrimazole presents anticancer properties against a mouse melanoma model acting as a PI3K inhibitor and inducing repolarization of tumor-associated macrophages.
Ochioni AC, Imbroisi Filho R, Esteves AM, Leandro JGB, Demaria TM, do Nascimento Júnior JX, Pereira-Dutra FS, Bozza PT, Sola-Penna M, Zancan P. Ochioni AC, et al. Among authors: leandro jgb. Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1;1867(12):166263. doi: 10.1016/j.bbadis.2021.166263. Epub 2021 Sep 2. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 34481868 Free article.
Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis.
Ausina P, Branco JR, Demaria TM, Esteves AM, Leandro JGB, Ochioni AC, Mendonça APM, Palhano FL, Oliveira MF, Abou-Kheir W, Sola-Penna M, Zancan P. Ausina P, et al. Among authors: leandro jgb. Sci Rep. 2020 Nov 12;10(1):19617. doi: 10.1038/s41598-020-76824-6. Sci Rep. 2020. PMID: 33184378 Free PMC article.