Leal SM - Search Results

1

Fine-scale patterns of population stratification confound rare variant association tests.

O'Connor TD, Kiezun A, Bamshad M, Rich SS, Smith JD, Turner E; NHLBIGO Exome Sequencing Project; ESP Population Genetics, Statistical Analysis Working Group; Leal SM, Akey JM. O'Connor TD, et al. Among authors: leal sm. PLoS One. 2013 Jul 4;8(7):e65834. doi: 10.1371/journal.pone.0065834. Print 2013. PLoS One. 2013. PMID: 23861739 Free PMC article.

2

Ignoring intermarker linkage disequilibrium induces false-positive evidence of linkage for consanguineous pedigrees when genotype data is missing for any pedigree member.

Li B, Leal SM. Li B, et al. Among authors: leal sm. Hum Hered. 2008;65(4):199-208. doi: 10.1159/000112367. Epub 2007 Dec 11. Hum Hered. 2008. PMID: 18073490 Free PMC article.

3

Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data.

Li B, Leal SM. Li B, et al. Among authors: leal sm. Am J Hum Genet. 2008 Sep;83(3):311-21. doi: 10.1016/j.ajhg.2008.06.024. Epub 2008 Aug 7. Am J Hum Genet. 2008. PMID: 18691683 Free PMC article.

4

Deviations from hardy-weinberg equilibrium in parental and unaffected sibling genotype data.

Li B, Leal SM. Li B, et al. Among authors: leal sm. Hum Hered. 2009;67(2):104-15. doi: 10.1159/000179558. Epub 2008 Dec 12. Hum Hered. 2009. PMID: 19077427 Free PMC article.

5

Discovery of rare variants via sequencing: implications for the design of complex trait association studies.

Li B, Leal SM. Li B, et al. Among authors: leal sm. PLoS Genet. 2009 May;5(5):e1000481. doi: 10.1371/journal.pgen.1000481. Epub 2009 May 15. PLoS Genet. 2009. PMID: 19436704 Free PMC article.

6

A novel adaptive method for the analysis of next-generation sequencing data to detect complex trait associations with rare variants due to gene main effects and interactions.

Liu DJ, Leal SM. Liu DJ, et al. Among authors: leal sm. PLoS Genet. 2010 Oct 14;6(10):e1001156. doi: 10.1371/journal.pgen.1001156. PLoS Genet. 2010. PMID: 20976247 Free PMC article.

7

GENOME-WIDE ASSOCIATION MAPPING AND RARE ALLELES: FROM POPULATION GENOMICS TO PERSONALIZED MEDICINE - Session Introduction.

DE LA Vega FM, Bustamante CD, Leal SM. DE LA Vega FM, et al. Among authors: leal sm. Pac Symp Biocomput. 2011:74-5. doi: 10.1142/9789814335058_0008. Pac Symp Biocomput. 2011. PMID: 21121034 Free PMC article.

8

Replication strategies for rare variant complex trait association studies via next-generation sequencing.

Liu DJ, Leal SM. Liu DJ, et al. Among authors: leal sm. Am J Hum Genet. 2010 Dec 10;87(6):790-801. doi: 10.1016/j.ajhg.2010.10.025. Am J Hum Genet. 2010. PMID: 21129725 Free PMC article.

9

Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia.

Brautbar A, Covarrubias D, Belmont J, Lara-Garduno F, Virani SS, Jones PH, Leal SM, Ballantyne CM. Brautbar A, et al. Among authors: leal sm. Atherosclerosis. 2011 Dec;219(2):737-42. doi: 10.1016/j.atherosclerosis.2011.08.015. Epub 2011 Aug 22. Atherosclerosis. 2011. PMID: 21889769 Free PMC article. Clinical Trial.

10

A flexible likelihood framework for detecting associations with secondary phenotypes in genetic studies using selected samples: application to sequence data.

Liu DJ, Leal SM. Liu DJ, et al. Among authors: leal sm. Eur J Hum Genet. 2012 Apr;20(4):449-56. doi: 10.1038/ejhg.2011.211. Epub 2011 Dec 14. Eur J Hum Genet. 2012. PMID: 22166943 Free PMC article.

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