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Anti-glioma properties of DVL, a lectin purified from Dioclea violacea.
Nascimento APM, Knaut JL, Rieger DK, Wolin IAV, Heinrich IA, Mann J, Juarez AV, Sosa LDV, De Paul AL, Moreira CG, Silva IB, Nobre CS, Osterne VJS, Nascimento KS, Cavada BS, Leal RB. Nascimento APM, et al. Among authors: leal rb. Int J Biol Macromol. 2018 Dec;120(Pt A):566-577. doi: 10.1016/j.ijbiomac.2018.08.106. Epub 2018 Aug 23. Int J Biol Macromol. 2018. PMID: 30145160 Free article.
ConBr lectin modulates MAPKs and Akt pathways and triggers autophagic glioma cell death by a mechanism dependent upon caspase-8 activation.
Wolin IAV, Heinrich IA, Nascimento APM, Welter PG, Sosa LDV, De Paul AL, Zanotto-Filho A, Nedel CB, Lima LD, Osterne VJS, Pinto-Junior VR, Nascimento KS, Cavada BS, Leal RB. Wolin IAV, et al. Among authors: leal rb. Biochimie. 2021 Jan;180:186-204. doi: 10.1016/j.biochi.2020.11.003. Epub 2020 Nov 7. Biochimie. 2021. PMID: 33171216 Free article.
The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats.
de Carvalho CR, Lopes MW, Constantino LC, Hoeller AA, de Melo HM, Guarnieri R, Linhares MN, Bortolotto ZA, Prediger RD, Latini A, Lin K, Licinio J, Leal RB, Walz R. de Carvalho CR, et al. Among authors: leal rb. Mol Psychiatry. 2021 Dec;26(12):7257-7269. doi: 10.1038/s41380-021-01203-0. Epub 2021 Jul 27. Mol Psychiatry. 2021. PMID: 34316004
134 results