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Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition.
Blanco-Aparicio C, Collazo AM, Oyarzabal J, Leal JF, Albarán MI, Lima FR, Pequeño B, Ajenjo N, Becerra M, Alfonso P, Reymundo MI, Palacios I, Mateos G, Quiñones H, Corrionero A, Carnero A, Pevarello P, Lopez AR, Fominaya J, Pastor J, Bischoff JR. Blanco-Aparicio C, et al. Among authors: leal jf. Cancer Lett. 2011 Jan 28;300(2):145-53. doi: 10.1016/j.canlet.2010.09.016. Epub 2010 Nov 3. Cancer Lett. 2011. PMID: 21051136
PTEN, more than the AKT pathway.
Blanco-Aparicio C, Renner O, Leal JF, Carnero A. Blanco-Aparicio C, et al. Among authors: leal jf. Carcinogenesis. 2007 Jul;28(7):1379-86. doi: 10.1093/carcin/bgm052. Epub 2007 Mar 6. Carcinogenesis. 2007. PMID: 17341655 Review.
PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma.
Gómez-Abad C, Pisonero H, Blanco-Aparicio C, Roncador G, González-Menchén A, Martinez-Climent JA, Mata E, Rodríguez ME, Muñoz-González G, Sánchez-Beato M, Leal JF, Bischoff JR, Piris MA. Gómez-Abad C, et al. Among authors: leal jf. Blood. 2011 Nov 17;118(20):5517-27. doi: 10.1182/blood-2011-03-344374. Epub 2011 Sep 21. Blood. 2011. PMID: 21937691 Free article.
Levels of p27(kip1) determine Aplidin sensitivity.
Moneo V, Serelde BG, Leal JF, Blanco-Aparicio C, Diaz-Uriarte R, Aracil M, Tercero JC, Jimeno J, Carnero A. Moneo V, et al. Among authors: leal jf. Mol Cancer Ther. 2007 Apr;6(4):1310-6. doi: 10.1158/1535-7163.MCT-06-0729. Mol Cancer Ther. 2007. PMID: 17431109
60 results