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Somatotropinomas, but not nonfunctioning pituitary adenomas, maintain a functional apoptotic RET/Pit1/ARF/p53 pathway that is blocked by excess GDNF.
Diaz-Rodriguez E, Garcia-Rendueles AR, Ibáñez-Costa A, Gutierrez-Pascual E, Garcia-Lavandeira M, Leal A, Japon MA, Soto A, Venegas E, Tinahones FJ, Garcia-Arnes JA, Benito P, Angeles Galvez M, Jimenez-Reina L, Bernabeu I, Dieguez C, Luque RM, Castaño JP, Alvarez CV. Diaz-Rodriguez E, et al. Among authors: leal a. Endocrinology. 2014 Nov;155(11):4329-40. doi: 10.1210/en.2014-1034. Epub 2014 Aug 19. Endocrinology. 2014. PMID: 25137025
Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors.
Durán-Prado M, Gahete MD, Martínez-Fuentes AJ, Luque RM, Quintero A, Webb SM, Benito-López P, Leal A, Schulz S, Gracia-Navarro F, Malagón MM, Castaño JP. Durán-Prado M, et al. Among authors: leal a. J Clin Endocrinol Metab. 2009 Jul;94(7):2634-43. doi: 10.1210/jc.2008-2564. Epub 2009 Apr 28. J Clin Endocrinol Metab. 2009. PMID: 19401364
744 results