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A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells.
Tan L, Duan X, Mutyala P, Zhou T, Amin S, Zhang T, Herbst B, Askan G, Itkin T, Xiang Z, Michelassi F, Lieberman MD, Iacobuzio-Donahue CA, Leach SD, Evans T, Chen S. Tan L, et al. Among authors: leach sd. J Mol Cell Biol. 2023 Nov 27;15(6):mjad039. doi: 10.1093/jmcb/mjad039. J Mol Cell Biol. 2023. PMID: 37327088 Free PMC article.
Ordered and deterministic cancer genome evolution after p53 loss.
Baslan T, Morris JP 4th, Zhao Z, Reyes J, Ho YJ, Tsanov KM, Bermeo J, Tian S, Zhang S, Askan G, Yavas A, Lecomte N, Erakky A, Varghese AM, Zhang A, Kendall J, Ghiban E, Chorbadjiev L, Wu J, Dimitrova N, Chadalavada K, Nanjangud GJ, Bandlamudi C, Gong Y, Donoghue MTA, Socci ND, Krasnitz A, Notta F, Leach SD, Iacobuzio-Donahue CA, Lowe SW. Baslan T, et al. Among authors: leach sd. Nature. 2022 Aug;608(7924):795-802. doi: 10.1038/s41586-022-05082-5. Epub 2022 Aug 17. Nature. 2022. PMID: 35978189 Free PMC article.
Prioritizing Measures That Matter Within a Person-Centered Oncology Learning Health System.
Van Citters AD, Kennedy AM, Kirkland KB, Dragnev KH, Leach SD, Buus-Frank ME, Malcolm EF, Holthoff MM, Holmes AB, Nelson EC, Reeves SA, Tosteson ANA; Promise Partnership Delphi Panel. Van Citters AD, et al. Among authors: leach sd. JNCI Cancer Spectr. 2022 May 2;6(3):pkac037. doi: 10.1093/jncics/pkac037. JNCI Cancer Spectr. 2022. PMID: 35736219 Free PMC article.
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer.
Joshi S, Gomes ED, Wang T, Corben A, Taldone T, Gandu S, Xu C, Sharma S, Buddaseth S, Yan P, Chan LYL, Gokce A, Rajasekhar VK, Shrestha L, Panchal P, Almodovar J, Digwal CS, Rodina A, Merugu S, Pillarsetty N, Miclea V, Peter RI, Wang W, Ginsberg SD, Tang L, Mattar M, de Stanchina E, Yu KH, Lowery M, Grbovic-Huezo O, O'Reilly EM, Janjigian Y, Healey JH, Jarnagin WR, Allen PJ, Sander C, Erdjument-Bromage H, Neubert TA, Leach SD, Chiosis G. Joshi S, et al. Among authors: leach sd. Commun Biol. 2021 Nov 25;4(1):1333. doi: 10.1038/s42003-021-02842-3. Commun Biol. 2021. PMID: 34824367 Free PMC article.
Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility.
Dhara S, Chhangawala S, Chintalapudi H, Askan G, Aveson V, Massa AL, Zhang L, Torres D, Makohon-Moore AP, Lecomte N, Melchor JP, Bermeo J, Cardenas A 3rd, Sinha S, Glassman D, Nicolle R, Moffitt R, Yu KH, Leppanen S, Laderman S, Curry B, Gui J, Balachandran VP, Iacobuzio-Donahue C, Chandwani R, Leslie CS, Leach SD. Dhara S, et al. Among authors: leach sd. Nat Commun. 2021 May 24;12(1):3044. doi: 10.1038/s41467-021-23237-2. Nat Commun. 2021. PMID: 34031415 Free PMC article.
Co-inhibition of SMAD and MAPK signaling enhances 124I uptake in BRAF-mutant thyroid cancers.
Luckett KA, Cracchiolo JR, Krishnamoorthy GP, Leandro-Garcia LJ, Nagarajah J, Saqcena M, Lester R, Im SY, Zhao Z, Lowe SW, de Stanchina E, Sherman EJ, Ho AL, Leach SD, Knauf JA, Fagin JA. Luckett KA, et al. Among authors: leach sd. Endocr Relat Cancer. 2021 May 18;28(6):391-402. doi: 10.1530/ERC-21-0017. Endocr Relat Cancer. 2021. PMID: 33890869 Free PMC article.
161 results