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Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates.
Hermet P, Delache B, Herate C, Wolf E, Kivi G, Juronen E, Mumm K, Žusinaite E, Kainov D, Sankovski E, Virumäe K, Planken A, Merits A, Besaw JE, Yee AW, Morizumi T, Kim K, Kuo A, Berriche A, Dereuddre-Bosquet N, Sconosciuti Q, Naninck T, Relouzat F, Cavarelli M, Ustav M, Wilson D, Ernst OP, Männik A, LeGrand R, Ustav M Jr. Hermet P, et al. Among authors: legrand r. PLoS Pathog. 2023 Aug 2;19(8):e1011532. doi: 10.1371/journal.ppat.1011532. eCollection 2023 Aug. PLoS Pathog. 2023. PMID: 37531329 Free PMC article.
Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates.
Marc A, Marlin R, Donati F, Prague M, Kerioui M, Hérate C, Alexandre M, Dereuddre-Bosquet N, Bertrand J, Contreras V, Behillil S, Maisonnasse P, Van Der Werf S, Le Grand R, Guedj J. Marc A, et al. PLoS Comput Biol. 2023 Aug 9;19(8):e1010721. doi: 10.1371/journal.pcbi.1010721. eCollection 2023 Aug. PLoS Comput Biol. 2023. PMID: 37556476 Free PMC article.
Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys.
Fenwick C, Turelli P, Duhoo Y, Lau K, Herate C, Marlin R, Lamrayah M, Campos J, Esteves-Leuenberger L, Farina A, Raclot C, Genet V, Fiscalini F, Cesborn J, Perez L, Dereuddre-Bosquet N, Contreras V, Lheureux K, Relouzat F, Abdelnabi R, Leyssen P, Lévy Y, Pojer F, Le Grand R, Trono D, Pantaleo G. Fenwick C, et al. J Infect. 2023 Dec;87(6):524-537. doi: 10.1016/j.jinf.2023.10.008. Epub 2023 Oct 16. J Infect. 2023. PMID: 37852477 Free article.
Azithromycin disrupts apicoplast biogenesis in replicating and dormant liver stages of the relapsing malaria parasites Plasmodium vivax and Plasmodium cynomolgi.
Amanzougaghene N, Tajeri S, Franetich JF, Ashraf K, Soulard V, Bigeard P, Guindo CO, Bouillier C, Lemaitre J, Relouzat F, Legrand R, Kocken CHM, Zeeman AM, Roobsoong W, Sattabongkot J, Yang Z, Snounou G, Mazier D. Amanzougaghene N, et al. Among authors: legrand r. Int J Antimicrob Agents. 2024 May;63(5):107112. doi: 10.1016/j.ijantimicag.2024.107112. Epub 2024 Feb 15. Int J Antimicrob Agents. 2024. PMID: 38367843 Free article.
Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses.
Tremain AC, Wallace RP, Lorentz KM, Thornley TB, Antane JT, Raczy MR, Reda JW, Alpar AT, Slezak AJ, Watkins EA, Maulloo CD, Budina E, Solanki A, Nguyen M, Bischoff DJ, Harrington JL, Mishra R, Conley GP, Marlin R, Dereuddre-Bosquet N, Gallouët AS, LeGrand R, Wilson DS, Kontos S, Hubbell JA. Tremain AC, et al. Among authors: legrand r. Nat Biomed Eng. 2023 Sep;7(9):1142-1155. doi: 10.1038/s41551-023-01086-2. Epub 2023 Sep 7. Nat Biomed Eng. 2023. PMID: 37679570
The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection.
Lécuyer D, Nardacci R, Tannous D, Gutierrez-Mateyron E, Deva Nathan A, Subra F, Di Primio C, Quaranta P, Petit V, Richetta C, Mostefa-Kara A, Del Nonno F, Falasca L, Marlin R, Maisonnasse P, Delahousse J, Pascaud J, Deprez E, Naigeon M, Chaput N, Paci A, Saada V, Ghez D, Mariette X, Costa M, Pistello M, Allouch A, Delelis O, Piacentini M, Le Grand R, Perfettini JL. Lécuyer D, et al. Front Immunol. 2023 Oct 18;14:1270081. doi: 10.3389/fimmu.2023.1270081. eCollection 2023. Front Immunol. 2023. PMID: 37920468 Free PMC article.
More rapid blood interferon α2 decline in fatal versus surviving COVID-19 patients.
Joly C, Desjardins D, Porcher R, Péré H, Bruneau T, Zhang Q, Bastard P, Cobat A, Resmini L, Lenoir O, Savale L, Lécuroux C, Verstuyft C, Roque-Afonso AM, Veyer D, Baron G, Resche-Rigon M, Ravaud P, Casanova JL, Le Grand R, Hermine O, Tharaux PL, Mariette X. Joly C, et al. Front Immunol. 2023 Nov 21;14:1250214. doi: 10.3389/fimmu.2023.1250214. eCollection 2023. Front Immunol. 2023. PMID: 38077399 Free PMC article.
Early blood neurofilament light chain and myelin oligodendrocyte glycoprotein antibody levels associate with different disease courses of myelin oligodendrocyte glycoprotein-associated disease in children.
Horellou P, Flet-Berliac L, Leroy C, Giorgi L, Joly C, Desjardins D, Chrétien P, Hacein-Bey-Abina S, Le Grand R, Deiva K. Horellou P, et al. Brain Commun. 2023 Mar 15;5(2):fcad063. doi: 10.1093/braincomms/fcad063. eCollection 2023. Brain Commun. 2023. PMID: 36993944 Free PMC article.
225 results