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High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling.
Gruber T, Lechner F, Murat C, Contreras RE, Sanchez-Quant E, Miok V, Makris K, Le Thuc O, González-García I, García-Clave E, Althammer F, Krabichler Q, DeCamp LM, Jones RG, Lutter D, Williams RH, Pfluger PT, Müller TD, Woods SC, Pospisilik JA, Martinez-Jimenez CP, Tschöp MH, Grinevich V, García-Cáceres C. Gruber T, et al. Among authors: le thuc o. Cell Rep. 2023 Oct 31;42(10):113305. doi: 10.1016/j.celrep.2023.113305. Cell Rep. 2023. PMID: 37864798 Free PMC article.
Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1.
González-García I, García-Clavé E, Cebrian-Serrano A, Le Thuc O, Contreras RE, Xu Y, Gruber T, Schriever SC, Legutko B, Lintelmann J, Adamski J, Wurst W, Müller TD, Woods SC, Pfluger PT, Tschöp MH, Fisette A, García-Cáceres C. González-García I, et al. Among authors: le thuc o. Cell Metab. 2023 Mar 7;35(3):438-455.e7. doi: 10.1016/j.cmet.2023.02.004. Cell Metab. 2023. PMID: 36889283 Free PMC article.
The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes.
Giroud M, Kotschi S, Kwon Y, Le Thuc O, Hoffmann A, Gil-Lozano M, Karbiener M, Higareda-Almaraz JC, Khani S, Tews D, Fischer-Posovszky P, Sun W, Dong H, Ghosh A, Wolfrum C, Wabitsch M, Virtanen KA, Blüher M, Nielsen S, Zeigerer A, García-Cáceres C, Scheideler M, Herzig S, Bartelt A. Giroud M, et al. Among authors: le thuc o. EMBO Rep. 2023 Oct 9;24(10):e57600. doi: 10.15252/embr.202357600. Epub 2023 Sep 6. EMBO Rep. 2023. PMID: 37671834 Free PMC article.
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.
Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, Legutko B, Ruiz-Ojeda FJ, Fuente-Fernández M, García-Villalón AL, González-Hedström D, Huber M, Szigeti-Buck K, Müller TD, Ussar S, Pfluger P, Woods SC, Ertürk A, LeDuc CA, Rahmouni K, Granado M, Horvath TL, Tschöp MH, García-Cáceres C. Gruber T, et al. Among authors: le thuc o. Cell Metab. 2021 Jun 1;33(6):1155-1170.e10. doi: 10.1016/j.cmet.2021.04.007. Epub 2021 May 4. Cell Metab. 2021. PMID: 33951475 Free PMC article.
Divide et impera: How mitochondrial fission in astrocytes rules obesity.
González-García I, Le Thuc O, Jastroch M, García-Cáceres C. González-García I, et al. Among authors: le thuc o. Mol Metab. 2021 Mar;45:101159. doi: 10.1016/j.molmet.2020.101159. Epub 2021 Jan 2. Mol Metab. 2021. PMID: 33400974 Free PMC article. No abstract available.
Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice.
Cansell C, Stobbe K, Sanchez C, Le Thuc O, Mosser CA, Ben-Fradj S, Leredde J, Lebeaupin C, Debayle D, Fleuriot L, Brau F, Devaux N, Benani A, Audinat E, Blondeau N, Nahon JL, Rovère C. Cansell C, et al. Among authors: le thuc o. Glia. 2021 Jan;69(1):42-60. doi: 10.1002/glia.23882. Epub 2020 Jul 13. Glia. 2021. PMID: 32659044
Functional identity of hypothalamic melanocortin neurons depends on Tbx3.
Quarta C, Fisette A, Xu Y, Colldén G, Legutko B, Tseng YT, Reim A, Wierer M, De Rosa MC, Klaus V, Rausch R, Thaker VV, Graf E, Strom TM, Poher AL, Gruber T, Le Thuc O, Cebrian-Serrano A, Kabra D, Bellocchio L, Woods SC, Pflugfelder GO, Nogueiras R, Zeltser L, Grunwald Kadow IC, Moon A, García-Cáceres C, Mann M, Treier M, Doege CA, Tschöp MH. Quarta C, et al. Among authors: le thuc o. Nat Metab. 2019 Feb;1(2):222-235. doi: 10.1038/s42255-018-0028-1. Epub 2019 Jan 28. Nat Metab. 2019. PMID: 32694784 Free PMC article.
18 results