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Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
Uhlenbrock N, Smith S, Weisner J, Landel I, Lindemann M, Le TA, Hardick J, Gontla R, Scheinpflug R, Czodrowski P, Janning P, Depta L, Quambusch L, Müller MP, Engels B, Rauh D. Uhlenbrock N, et al. Among authors: le ta. Chem Sci. 2019 Feb 13;10(12):3573-3585. doi: 10.1039/c8sc05212c. eCollection 2019 Mar 28. Chem Sci. 2019. PMID: 30996949 Free PMC article.
Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.
Wagner A, Le TA, Brennich M, Klein P, Bader N, Diehl E, Paszek D, Weickhmann AK, Dirdjaja N, Krauth-Siegel RL, Engels B, Opatz T, Schindelin H, Hellmich UA. Wagner A, et al. Among authors: le ta. Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3640-3644. doi: 10.1002/anie.201810470. Epub 2019 Jan 30. Angew Chem Int Ed Engl. 2019. PMID: 30605929
A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure.
Eltschkner S, Kehrein J, Le TA, Davoodi S, Merget B, Basak S, Weinrich JD, Schiebel J, Tonge PJ, Engels B, Sotriffer C, Kisker C. Eltschkner S, et al. Among authors: le ta. ACS Infect Dis. 2021 Apr 9;7(4):746-758. doi: 10.1021/acsinfecdis.0c00437. Epub 2021 Mar 12. ACS Infect Dis. 2021. PMID: 33710875 Free PMC article.
Real-world analysis of afatinib as a first-line treatment for patients with advanced stage non-small-cell lung cancer with uncommon EGFR mutations: a multicenter study in Vietnam.
Pham VL, Le TA, Pham CP, Hoa Nguyen TT, Do AT, Nguyen TK, Nguyen MH, Thu Hoang TA, Hao Vuong DT, Tam Nguyen DN, Khiem Dang V, Nguyen TO, Trang Vo TH, Do HK, Vu HT, Nguyen TTH, Pham VT, Trinh LH, Dung Nguyen K, Nguyen HG, Truong CM, Chau Pham TM, Nguyen TBP. Pham VL, et al. Among authors: le ta. Ther Adv Med Oncol. 2024 May 9;16:17588359241242972. doi: 10.1177/17588359241242972. eCollection 2024. Ther Adv Med Oncol. 2024. PMID: 38736554 Free PMC article.
PEGylated Liposomes for Diagnosis of Polyethylene Glycol Allergy.
Perkins GB, Tunbridge MJ, Hurtado PR, Zuiani J, Mhatre S, Yip KH, Le TA, Yuson C, Kette F, Hissaria P. Perkins GB, et al. Among authors: le ta. J Allergy Clin Immunol. 2024 May 6:S0091-6749(24)00456-1. doi: 10.1016/j.jaci.2024.03.030. Online ahead of print. J Allergy Clin Immunol. 2024. PMID: 38718949 Free article.
196 results