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Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade.
Patel RB, Hernandez R, Carlson P, Grudzinski J, Bates AM, Jagodinsky JC, Erbe A, Marsh IR, Arthur I, Aluicio-Sarduy E, Sriramaneni RN, Jin WJ, Massey C, Rakhmilevich AL, Vail D, Engle JW, Le T, Kim K, Bednarz B, Sondel PM, Weichert J, Morris ZS. Patel RB, et al. Among authors: le t. Sci Transl Med. 2021 Jul 14;13(602):eabb3631. doi: 10.1126/scitranslmed.abb3631. Sci Transl Med. 2021. PMID: 34261797 Free PMC article.
In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases.
Clark PA, Sriramaneni RN, Jin WJ, Jagodinsky JC, Bates AM, Jaquish AA, Anderson BR, Le T, Lubin JA, Chakravarty I, Arthur IS, Heinze CM, Guy EI, Kler J, Klar KA, Carlson PM, Kim KM, Kuo JS, Morris ZS. Clark PA, et al. Among authors: le t. J Immunother Cancer. 2020 Jul;8(2):e000809. doi: 10.1136/jitc-2020-000809. J Immunother Cancer. 2020. PMID: 32690669 Free PMC article.
Tumor-Specific Antibody, Cetuximab, Enhances the In Situ Vaccine Effect of Radiation in Immunologically Cold Head and Neck Squamous Cell Carcinoma.
Jin WJ, Erbe AK, Schwarz CN, Jaquish AA, Anderson BR, Sriramaneni RN, Jagodinsky JC, Bates AM, Clark PA, Le T, Lan KH, Chen Y, Kim K, Morris ZS. Jin WJ, et al. Among authors: le t. Front Immunol. 2020 Nov 12;11:591139. doi: 10.3389/fimmu.2020.591139. eCollection 2020. Front Immunol. 2020. PMID: 33281820 Free PMC article.
Low-Dose Radiation Potentiates the Propagation of Anti-Tumor Immunity against Melanoma Tumor in the Brain after In Situ Vaccination at a Tumor outside the Brain.
Clark PA, Sriramaneni RN, Bates AM, Jin WJ, Jagodinsky JC, Hernandez R, Le T, Jeffery JJ, Marsh IR, Grudzinski JJ, Aluicio-Sarduy E, Barnhart TE, Anderson BR, Chakravarty I, Arthur IS, Kim K, Engle JW, Bednarz BP, Weichert JP, Morris ZS. Clark PA, et al. Among authors: le t. Radiat Res. 2021 Jun 1;195(6):522-540. doi: 10.1667/RADE-20-00237.1. Radiat Res. 2021. PMID: 33826741 Free PMC article.
Combination of Bempegaldesleukin and Anti-CTLA-4 Prevents Metastatic Dissemination After Primary Resection or Radiotherapy in a Preclinical Model of Non-Small Cell Lung Cancer.
Bates AM, Brown RJ, Pieper AA, Zangl LM, Arthur I, Carlson PM, Le T, Sosa GA, Clark PA, Sriramaneni RN, Kim K, Patel RB, Morris ZS. Bates AM, et al. Among authors: le t. Front Oncol. 2021 Apr 15;11:645352. doi: 10.3389/fonc.2021.645352. eCollection 2021. Front Oncol. 2021. PMID: 33937052 Free PMC article.
Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy.
Jagodinsky JC, Jin WJ, Bates AM, Hernandez R, Grudzinski JJ, Marsh IR, Chakravarty I, Arthur IS, Zangl LM, Brown RJ, Nystuen EJ, Emma SE, Kerr C, Carlson PM, Sriramaneni RN, Engle JW, Aluicio-Sarduy E, Barnhart TE, Le T, Kim K, Bednarz BP, Weichert JP, Patel RB, Morris ZS. Jagodinsky JC, et al. Among authors: le t. Theranostics. 2021 Apr 15;11(13):6120-6137. doi: 10.7150/thno.54881. eCollection 2021. Theranostics. 2021. PMID: 33995649 Free PMC article.
Radiation Augments the Local Anti-Tumor Effect of In Situ Vaccine With CpG-Oligodeoxynucleotides and Anti-OX40 in Immunologically Cold Tumor Models.
Pieper AA, Zangl LM, Speigelman DV, Feils AS, Hoefges A, Jagodinsky JC, Felder MA, Tsarovsky NW, Arthur IS, Brown RJ, Birstler J, Le T, Carlson PM, Bates AM, Hank JA, Rakhmilevich AL, Erbe AK, Sondel PM, Patel RB, Morris ZS. Pieper AA, et al. Among authors: le t. Front Immunol. 2021 Nov 15;12:763888. doi: 10.3389/fimmu.2021.763888. eCollection 2021. Front Immunol. 2021. PMID: 34868010 Free PMC article.
Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade.
Zhang Y, Sriramaneni RN, Clark PA, Jagodinsky JC, Ye M, Jin W, Wang Y, Bates A, Kerr CP, Le T, Allawi R, Wang X, Xie R, Havighurst TC, Chakravarty I, Rakhmilevich AL, O'Leary KA, Schuler LA, Sondel PM, Kim K, Gong S, Morris ZS. Zhang Y, et al. Among authors: le t. Nat Commun. 2022 Aug 23;13(1):4948. doi: 10.1038/s41467-022-32645-x. Nat Commun. 2022. PMID: 35999216 Free PMC article.
NK cells propagate T cell immunity following in situ tumor vaccination.
Jin WJ, Jagodinsky JC, Vera JM, Clark PA, Zuleger CL, Erbe AK, Ong IM, Le T, Tetreault K, Berg T, Rakhmilevich AL, Kim K, Newton MA, Albertini MR, Sondel PM, Morris ZS. Jin WJ, et al. Among authors: le t. Cell Rep. 2023 Dec 26;42(12):113556. doi: 10.1016/j.celrep.2023.113556. Epub 2023 Dec 13. Cell Rep. 2023. PMID: 38096050 Free PMC article.
Antibody landscape of C57BL/6 mice cured of B78 melanoma via a combined radiation and immunocytokine immunotherapy regimen.
Hoefges A, McIlwain SJ, Erbe AK, Mathers N, Xu A, Melby D, Tetreault K, Le T, Kim K, Pinapati RS, Garcia BH, Patel J, Heck M, Feils AS, Tsarovsky N, Hank JA, Morris ZS, Ong IM, Sondel PM. Hoefges A, et al. Among authors: le t. Front Immunol. 2023 Nov 23;14:1221155. doi: 10.3389/fimmu.2023.1221155. eCollection 2023. Front Immunol. 2023. PMID: 38077403 Free PMC article.
4,883 results