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Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.
Oshima M, Pechberty S, Bellini L, Göpel SO, Campana M, Rouch C, Dairou J, Cosentino C, Fantuzzi F, Toivonen S, Marchetti P, Magnan C, Cnop M, Le Stunff H, Scharfmann R. Oshima M, et al. Among authors: le stunff h. Diabetologia. 2020 Feb;63(2):395-409. doi: 10.1007/s00125-019-05046-x. Epub 2019 Dec 3. Diabetologia. 2020. PMID: 31796987 Free PMC article.
Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes.
Bellini L, Campana M, Mahfouz R, Carlier A, Véret J, Magnan C, Hajduch E, Le Stunff H. Bellini L, et al. Among authors: le stunff h. Expert Opin Ther Targets. 2015;19(8):1037-50. doi: 10.1517/14728222.2015.1028359. Epub 2015 Mar 26. Expert Opin Ther Targets. 2015. PMID: 25814122 Review.
Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans.
Wigger L, Cruciani-Guglielmacci C, Nicolas A, Denom J, Fernandez N, Fumeron F, Marques-Vidal P, Ktorza A, Kramer W, Schulte A, Le Stunff H, Liechti R, Xenarios I, Vollenweider P, Waeber G, Uphues I, Roussel R, Magnan C, Ibberson M, Thorens B. Wigger L, et al. Among authors: le stunff h. Cell Rep. 2017 Feb 28;18(9):2269-2279. doi: 10.1016/j.celrep.2017.02.019. Cell Rep. 2017. PMID: 28249170 Free article.
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.
Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M. Cruciani-Guglielmacci C, et al. Among authors: le stunff h. Mol Metab. 2017 Jan 26;6(4):340-351. doi: 10.1016/j.molmet.2017.01.009. eCollection 2017 Apr. Mol Metab. 2017. PMID: 28377873 Free PMC article.
Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice.
Laperrousaz E, Moullé VS, Denis RG, Kassis N, Berland C, Colsch B, Fioramonti X, Philippe E, Lacombe A, Vanacker C, Butin N, Bruce KD, Wang H, Wang Y, Gao Y, Garcia-Caceres C, Prévot V, Tschöp MH, Eckel RH, Le Stunff H, Luquet S, Magnan C, Cruciani-Guglielmacci C. Laperrousaz E, et al. Among authors: le stunff h. Diabetologia. 2017 Jul;60(7):1314-1324. doi: 10.1007/s00125-017-4282-7. Epub 2017 Apr 29. Diabetologia. 2017. PMID: 28456865
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