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The pathogenesis of mesothelioma is driven by a dysregulated translatome.
Grosso S, Marini A, Gyuraszova K, Voorde JV, Sfakianos A, Garland GD, Tenor AR, Mordue R, Chernova T, Morone N, Sereno M, Smith CP, Officer L, Farahmand P, Rooney C, Sumpton D, Das M, Teodósio A, Ficken C, Martin MG, Spriggs RV, Sun XM, Bushell M, Sansom OJ, Murphy D, MacFarlane M, Le Quesne JPC, Willis AE. Grosso S, et al. Among authors: le quesne jpc. Nat Commun. 2021 Aug 13;12(1):4920. doi: 10.1038/s41467-021-25173-7. Nat Commun. 2021. PMID: 34389715 Free PMC article.
Dysregulation of protein synthesis and disease.
Le Quesne JP, Spriggs KA, Bushell M, Willis AE. Le Quesne JP, et al. J Pathol. 2010 Jan;220(2):140-51. doi: 10.1002/path.2627. J Pathol. 2010. PMID: 19827082 Review.
Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf).
Chernova T, Murphy FA, Galavotti S, Sun XM, Powley IR, Grosso S, Schinwald A, Zacarias-Cabeza J, Dudek KM, Dinsdale D, Le Quesne J, Bennett J, Nakas A, Greaves P, Poland CA, Donaldson K, Bushell M, Willis AE, MacFarlane M. Chernova T, et al. Curr Biol. 2017 Nov 6;27(21):3302-3314.e6. doi: 10.1016/j.cub.2017.09.007. Curr Biol. 2017. PMID: 29112861 Free PMC article.
The ERBB network facilitates KRAS-driven lung tumorigenesis.
Kruspig B, Monteverde T, Neidler S, Hock A, Kerr E, Nixon C, Clark W, Hedley A, Laing S, Coffelt SB, Le Quesne J, Dick C, Vousden KH, Martins CP, Murphy DJ. Kruspig B, et al. Sci Transl Med. 2018 Jun 20;10(446):eaao2565. doi: 10.1126/scitranslmed.aao2565. Sci Transl Med. 2018. PMID: 29925636 Free PMC article.
Genomic instability in mutant p53 cancer cells upon entotic engulfment.
Mackay HL, Moore D, Hall C, Birkbak NJ, Jamal-Hanjani M, Karim SA, Phatak VM, Piñon L, Morton JP, Swanton C, Le Quesne J, Muller PAJ. Mackay HL, et al. Nat Commun. 2018 Aug 3;9(1):3070. doi: 10.1038/s41467-018-05368-1. Nat Commun. 2018. PMID: 30076358 Free PMC article.
82 results