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Safety and immunogenicity of Ad26.COV2.S in adults: A randomised, double-blind, placebo-controlled Phase 2a dose-finding study.
Cárdenas V, Le Gars M, Truyers C, Ruiz-Guiñazú J, Struyf F, Colfer A, Bonten M, Borobia A, Reisinger EC, Kamerling IMC, Douoguih M, Sadoff J. Cárdenas V, et al. Among authors: le gars m. Vaccine. 2024 May 4:S0264-410X(24)00496-1. doi: 10.1016/j.vaccine.2024.04.059. Online ahead of print. Vaccine. 2024. PMID: 38705804 Free article.
B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S.
Jacob-Dolan C, Lifton M, Powers OC, Miller J, Hachmann NP, Vu M, Surve N, Mazurek CR, Fisher JL, Rodrigues S, Patio RC, Anand T, Le Gars M, Sadoff J, Schmidt AG, Barouch DH. Jacob-Dolan C, et al. Among authors: le gars m. iScience. 2024 Apr 9;27(5):109716. doi: 10.1016/j.isci.2024.109716. eCollection 2024 May 17. iScience. 2024. PMID: 38655202 Free PMC article.
Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features.
Magaret CA, Li L, deCamp AC, Rolland M, Juraska M, Williamson BD, Ludwig J, Molitor C, Benkeser D, Luedtke A, Simpkins B, Heng F, Sun Y, Carpp LN, Bai H, Dearlove BL, Giorgi EE, Jongeneelen M, Brandenburg B, McCallum M, Bowen JE, Veesler D, Sadoff J, Gray GE, Roels S, Vandebosch A, Stieh DJ, Le Gars M, Vingerhoets J, Grinsztejn B, Goepfert PA, de Sousa LP, Silva MST, Casapia M, Losso MH, Little SJ, Gaur A, Bekker LG, Garrett N, Truyers C, Van Dromme I, Swann E, Marovich MA, Follmann D, Neuzil KM, Corey L, Greninger AL, Roychoudhury P, Hyrien O, Gilbert PB. Magaret CA, et al. Among authors: le gars m. Nat Commun. 2024 Mar 11;15(1):2175. doi: 10.1038/s41467-024-46536-w. Nat Commun. 2024. PMID: 38467646 Free PMC article.
Mechanistic modeling projections of antibody persistence after homologous booster regimens of COVID-19 vaccine Ad26.COV2.S in humans.
Dari A, Jacqmin P, Iwaki Y, Neyens M, Le Gars M, Sadoff J, Hardt K, Ruiz-Guiñazú J, Pérez-Ruixo JJ. Dari A, et al. Among authors: le gars m. CPT Pharmacometrics Syst Pharmacol. 2023 Oct;12(10):1485-1498. doi: 10.1002/psp4.13025. Epub 2023 Sep 15. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37715342 Free PMC article.
Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines.
Van Coillie J, Pongracz T, Šuštić T, Wang W, Nouta J, Le Gars M, Keijzer S, Linty F, Cristianawati O, Keijser JBD, Visser R, van Vught LA, Slim MA, van Mourik N, Smit MJ, Sander A, Schmidt DE, Steenhuis M, Rispens T, Nielsen MA, Mordmüller BG, Vlaar APJ, Ellen van der Schoot C, Roozendaal R, Wuhrer M, Vidarsson G; UMC COVID-19 S3/HCW study group; Fatebenefratelli-Sacco Infectious Diseases Physicians group; Radboud University Medical Center (RUMC) and COUGH1 study group. Van Coillie J, et al. Among authors: le gars m. iScience. 2023 Aug 14;26(9):107619. doi: 10.1016/j.isci.2023.107619. eCollection 2023 Sep 15. iScience. 2023. PMID: 37670790 Free PMC article.
Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features.
Magaret C, Li L, deCamp A, Rolland M, Juraska M, Williamson B, Ludwig J, Molitor C, Benkeser D, Luedtke A, Simpkins B, Carpp L, Bai H, Deariove B, Greninger A, Roychoudhury P, Sadoff J, Gray G, Roels S, Vandebosch A, Stieh D, Le Gars M, Vingerhoets J, Grinsztejn B, Goepfert P, Truyers C, Van Dromme I, Swann E, Marovich M, Follmann D, Neuzil K, Corey L, Hyrien O, Paiva de Sousa L, Casapia M, Losso M, Little S, Gaur A, Bekker LG, Garrett N, Heng F, Sun Y, Gilbert P. Magaret C, et al. Among authors: le gars m. Res Sq [Preprint]. 2023 May 31:rs.3.rs-2743022. doi: 10.21203/rs.3.rs-2743022/v1. Res Sq. 2023. PMID: 37398105 Free PMC article. Updated. Preprint.
Quantifying Antibody Persistence After a Single Dose of COVID-19 Vaccine Ad26.COV2.S in Humans Using a Mechanistic Modeling and Simulation Approach.
Dari A, Boulton M, Neyens M, Le Gars M, Valenzuela B, Shukarev G, Cárdenas V, Ruiz-Guiñazú J, Sadoff J, Hoetelmans RMW, Ruixo JJP. Dari A, et al. Among authors: le gars m. Clin Pharmacol Ther. 2023 Feb;113(2):380-389. doi: 10.1002/cpt.2796. Epub 2022 Dec 9. Clin Pharmacol Ther. 2023. PMID: 36377532 Free PMC article.
33 results