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Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus.
Pawlik A, Garnier G, Orgeur M, Tong P, Lohan A, Le Chevalier F, Sapriel G, Roux AL, Conlon K, Honoré N, Dillies MA, Ma L, Bouchier C, Coppée JY, Gaillard JL, Gordon SV, Loftus B, Brosch R, Herrmann JL. Pawlik A, et al. Among authors: le chevalier f. Mol Microbiol. 2013 Nov;90(3):612-29. doi: 10.1111/mmi.12387. Epub 2013 Sep 17. Mol Microbiol. 2013. PMID: 23998761 Free article.
Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice.
Bakala N'Goma JC, Le Moigne V, Soismier N, Laencina L, Le Chevalier F, Roux AL, Poncin I, Serveau-Avesque C, Rottman M, Gaillard JL, Etienne G, Brosch R, Herrmann JL, Canaan S, Girard-Misguich F. Bakala N'Goma JC, et al. Among authors: le chevalier f, le moigne v. Infect Immun. 2015 Feb;83(2):780-91. doi: 10.1128/IAI.02032-14. Epub 2014 Dec 8. Infect Immun. 2015. PMID: 25486995 Free PMC article.
pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence.
Boritsch EC, Frigui W, Cascioferro A, Malaga W, Etienne G, Laval F, Pawlik A, Le Chevalier F, Orgeur M, Ma L, Bouchier C, Stinear TP, Supply P, Majlessi L, Daffé M, Guilhot C, Brosch R. Boritsch EC, et al. Among authors: le chevalier f. Nat Microbiol. 2016 Jan 27;1:15019. doi: 10.1038/nmicrobiol.2015.19. Nat Microbiol. 2016. PMID: 27571976
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.
Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar-Adler NR, Bottrill AR, le Chevalier F, Frigui W, Bellinzoni M, Lisa MN, Alzari PM, Nguyen L, Brosch R, Sauer U, Manganelli R, O'Hare HM. Rieck B, et al. Among authors: le chevalier f. PLoS Pathog. 2017 May 17;13(5):e1006399. doi: 10.1371/journal.ppat.1006399. eCollection 2017 May. PLoS Pathog. 2017. PMID: 28545104 Free PMC article.
Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis.
Ates LS, Dippenaar A, Ummels R, Piersma SR, van der Woude AD, van der Kuij K, Le Chevalier F, Mata-Espinosa D, Barrios-Payán J, Marquina-Castillo B, Guapillo C, Jiménez CR, Pain A, Houben ENG, Warren RM, Brosch R, Hernández-Pando R, Bitter W. Ates LS, et al. Among authors: le chevalier f. Nat Microbiol. 2018 Feb;3(2):181-188. doi: 10.1038/s41564-017-0090-6. Epub 2018 Jan 15. Nat Microbiol. 2018. PMID: 29335553
Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors.
Sayes F, Blanc C, Ates LS, Deboosere N, Orgeur M, Le Chevalier F, Gröschel MI, Frigui W, Song OR, Lo-Man R, Brossier F, Sougakoff W, Bottai D, Brodin P, Charneau P, Brosch R, Majlessi L. Sayes F, et al. Among authors: le chevalier f. Cell Rep. 2018 Apr 24;23(4):1072-1084. doi: 10.1016/j.celrep.2018.03.125. Cell Rep. 2018. PMID: 29694886 Free PMC article.
An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.
Vesin B, Lopez J, Noirat A, Authié P, Fert I, Le Chevalier F, Moncoq F, Nemirov K, Blanc C, Planchais C, Mouquet H, Guinet F, Hardy D, Vives FL, Gerke C, Anna F, Bourgine M, Majlessi L, Charneau P. Vesin B, et al. Among authors: le chevalier f. Mol Ther. 2022 Sep 7;30(9):2984-2997. doi: 10.1016/j.ymthe.2022.04.016. Epub 2022 Apr 27. Mol Ther. 2022. PMID: 35484842 Free PMC article.
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