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Comprehensive survey of combinatorial library synthesis: 2005.
Dolle RE, Le Bourdonnec B, Morales GA, Moriarty KJ, Salvino JM. Dolle RE, et al. Among authors: le bourdonnec b. J Comb Chem. 2006 Sep-Oct;8(5):597-635. doi: 10.1021/cc060095m. J Comb Chem. 2006. PMID: 16961395 Review. No abstract available.
Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists.
Le Bourdonnec B, Goodman AJ, Graczyk TM, Belanger S, Seida PR, DeHaven RN, Dolle RE. Le Bourdonnec B, et al. J Med Chem. 2006 Dec 14;49(25):7290-306. doi: 10.1021/jm0604878. J Med Chem. 2006. PMID: 17149859
To better understand structural requirements for a mu ligand of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class to interact with the mu opioid receptor, we have described in the previous article (Le Bourdonnec, B. et al. J. Med. Chem. 2006, 25, 727 …
To better understand structural requirements for a mu ligand of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class to interact with …
Discovery of a series of aminopiperidines as novel iNOS inhibitors.
Le Bourdonnec B, Leister LK, Ajello CA, Cassel JA, Seida PR, O'Hare H, Gu M, Chu GH, Tuthill PA, DeHaven RN, Dolle RE. Le Bourdonnec B, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):336-43. doi: 10.1016/j.bmcl.2007.10.073. Epub 2007 Oct 25. Bioorg Med Chem Lett. 2008. PMID: 18024030
Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
Le Bourdonnec B, Windh RT, Ajello CW, Leister LK, Gu M, Chu GH, Tuthill PA, Barker WM, Koblish M, Wiant DD, Graczyk TM, Belanger S, Cassel JA, Feschenko MS, Brogdon BL, Smith SA, Christ DD, Derelanko MJ, Kutz S, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE. Le Bourdonnec B, et al. J Med Chem. 2008 Oct 9;51(19):5893-6. doi: 10.1021/jm8008986. Epub 2008 Sep 13. J Med Chem. 2008. PMID: 18788723
33 results