León R - Search Results

1

Curcumin-Piperlongumine Hybrids with a Multitarget Profile Elicit Neuroprotection in In Vitro Models of Oxidative Stress and Hyperphosphorylation.

Cores Á, Carmona-Zafra N, Martín-Cámara O, Sánchez JD, Duarte P, Villacampa M, Bermejo-Bescós P, Martín-Aragón S, León R, Menéndez JC. Cores Á, et al. Among authors: leon r. Antioxidants (Basel). 2021 Dec 24;11(1):28. doi: 10.3390/antiox11010028. Antioxidants (Basel). 2021. PMID: 35052532 Free PMC article.

2

New 5-unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury.

Tenti G, Parada E, León R, Egea J, Martínez-Revelles S, Briones AM, Sridharan V, López MG, Ramos MT, Menéndez JC. Tenti G, et al. Among authors: leon r. J Med Chem. 2014 May 22;57(10):4313-23. doi: 10.1021/jm500263v. Epub 2014 May 7. J Med Chem. 2014. PMID: 24754640

3

ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia.

Buendia I, Tenti G, Michalska P, Méndez-López I, Luengo E, Satriani M, Padín-Nogueira F, López MG, Ramos MT, García AG, Menéndez JC, León R. Buendia I, et al. Among authors: leon r. ACS Chem Neurosci. 2017 Jan 18;8(1):67-81. doi: 10.1021/acschemneuro.6b00181. Epub 2016 Nov 22. ACS Chem Neurosci. 2017. PMID: 27731633

4

Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease.

Gameiro I, Michalska P, Tenti G, Cores Á, Buendia I, Rojo AI, Georgakopoulos ND, Hernández-Guijo JM, Teresa Ramos M, Wells G, López MG, Cuadrado A, Menéndez JC, León R. Gameiro I, et al. Among authors: leon r. Sci Rep. 2017 Mar 31;7:45701. doi: 10.1038/srep45701. Sci Rep. 2017. PMID: 28361919 Free PMC article.

5

Aza-CGP37157-lipoic hybrids designed as novel Nrf2-inducers and antioxidants exert neuroprotection against oxidative stress and show neuroinflammation inhibitory properties.

Michalska P, Tenti G, Satriani M, Cores A, Ramos MT, García AG, Menéndez JC, León R. Michalska P, et al. Among authors: leon r. Drug Dev Res. 2020 May;81(3):283-294. doi: 10.1002/ddr.21618. Epub 2019 Nov 6. Drug Dev Res. 2020. PMID: 31693218

6

Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization.

Michalska P, Buendia I, Duarte P, FernandezMendivil C, Negredo P, Cuadrado A, López MG, Leon R. Michalska P, et al. Among authors: leon r. Pharmacol Res. 2020 Feb;152:104597. doi: 10.1016/j.phrs.2019.104597. Epub 2019 Dec 12. Pharmacol Res. 2020. PMID: 31838078

7

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.

Herrera-Arozamena C, Estrada-Valencia M, Pérez C, Lagartera L, Morales-García JA, Pérez-Castillo A, Franco-Gonzalez JF, Michalska P, Duarte P, León R, López MG, Mills A, Gago F, García-Yagüe ÁJ, Fernández-Ginés R, Cuadrado A, Rodríguez-Franco MI. Herrera-Arozamena C, et al. Among authors: leon r. Eur J Med Chem. 2020 Mar 15;190:112090. doi: 10.1016/j.ejmech.2020.112090. Epub 2020 Jan 25. Eur J Med Chem. 2020. PMID: 32018096 Free article.

8

NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases.

Cores Á, Piquero M, Villacampa M, León R, Menéndez JC. Cores Á, et al. Among authors: leon r. Biomolecules. 2020 Jun 14;10(6):904. doi: 10.3390/biom10060904. Biomolecules. 2020. PMID: 32545924 Free PMC article. Review.

9

Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer's Disease.

Michalska P, Mayo P, Fernández-Mendívil C, Tenti G, Duarte P, Buendia I, Ramos MT, López MG, Menéndez JC, León R. Michalska P, et al. Among authors: leon r. Antioxidants (Basel). 2020 Jul 22;9(8):650. doi: 10.3390/antiox9080650. Antioxidants (Basel). 2020. PMID: 32708053 Free PMC article.

10

When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration.

Michalska P, León R. Michalska P, et al. Among authors: leon r. Antioxidants (Basel). 2020 Aug 12;9(8):740. doi: 10.3390/antiox9080740. Antioxidants (Basel). 2020. PMID: 32806679 Free PMC article. Review.

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