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Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Mol Cell. 2023 May 18;83(10):1725-1742.e12. doi: 10.1016/j.molcel.2023.03.026. Epub 2023 Apr 20.
Mol Cell. 2023.
PMID: 37084731
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, Lazear MR, Yin S, Blewett MM, Dix MM, Nguyen N, Shokhirev MN, Chin EN, Lairson LL, Melillo B, Schreiber SL, Forli S, Teijaro JR, Cravatt BF.
Vinogradova EV, et al. Among authors: lazear mr.
Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
Cell. 2020.
PMID: 32730809
Free PMC article.
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Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors.
Niessen S, Dix MM, Barbas S, Potter ZE, Lu S, Brodsky O, Planken S, Behenna D, Almaden C, Gajiwala KS, Ryan K, Ferre R, Lazear MR, Hayward MM, Kath JC, Cravatt BF.
Niessen S, et al. Among authors: lazear mr.
Cell Chem Biol. 2017 Nov 16;24(11):1388-1400.e7. doi: 10.1016/j.chembiol.2017.08.017. Epub 2017 Sep 28.
Cell Chem Biol. 2017.
PMID: 28965727
Free PMC article.
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A proteome-wide atlas of lysine-reactive chemistry.
Abbasov ME, Kavanagh ME, Ichu TA, Lazear MR, Tao Y, Crowley VM, Am Ende CW, Hacker SM, Ho J, Dix MM, Suciu R, Hayward MM, Kiessling LL, Cravatt BF.
Abbasov ME, et al. Among authors: lazear mr.
Nat Chem. 2021 Nov;13(11):1081-1092. doi: 10.1038/s41557-021-00765-4. Epub 2021 Sep 9.
Nat Chem. 2021.
PMID: 34504315
Free PMC article.
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Global profiling of lysine reactivity and ligandability in the human proteome.
Hacker SM, Backus KM, Lazear MR, Forli S, Correia BE, Cravatt BF.
Hacker SM, et al. Among authors: lazear mr.
Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
Nat Chem. 2017.
PMID: 29168484
Free PMC article.
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Publisher Correction: A proteome-wide atlas of lysine-reactive chemistry.
Abbasov ME, Kavanagh ME, Ichu TA, Lazear MR, Tao Y, Crowley VM, Am Ende CW, Hacker SM, Ho J, Dix MM, Suciu R, Hayward MM, Kiessling LL, Cravatt BF.
Abbasov ME, et al. Among authors: lazear mr.
Nat Chem. 2021 Nov;13(11):1151. doi: 10.1038/s41557-021-00823-x.
Nat Chem. 2021.
PMID: 34588639
No abstract available.
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Sage: An Open-Source Tool for Fast Proteomics Searching and Quantification at Scale.
Lazear MR.
Lazear MR.
J Proteome Res. 2023 Nov 3;22(11):3652-3659. doi: 10.1021/acs.jproteome.3c00486. Epub 2023 Oct 11.
J Proteome Res. 2023.
PMID: 37819886
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