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Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Lazear MR, Remsberg JR, Jaeger MG, Rothamel K, Her HL, DeMeester KE, Njomen E, Hogg SJ, Rahman J, Whitby LR, Won SJ, Schafroth MA, Ogasawara D, Yokoyama M, Lindsey GL, Li H, Germain J, Barbas S, Vaughan J, Hanigan TW, Vartabedian VF, Reinhardt CJ, Dix MM, Koo SJ, Heo I, Teijaro JR, Simon GM, Ghosh B, Abdel-Wahab O, Ahn K, Saghatelian A, Melillo B, Schreiber SL, Yeo GW, Cravatt BF. Lazear MR, et al. Mol Cell. 2023 May 18;83(10):1725-1742.e12. doi: 10.1016/j.molcel.2023.03.026. Epub 2023 Apr 20. Mol Cell. 2023. PMID: 37084731
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, Lazear MR, Yin S, Blewett MM, Dix MM, Nguyen N, Shokhirev MN, Chin EN, Lairson LL, Melillo B, Schreiber SL, Forli S, Teijaro JR, Cravatt BF. Vinogradova EV, et al. Among authors: lazear mr. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29. Cell. 2020. PMID: 32730809 Free PMC article.
Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors.
Niessen S, Dix MM, Barbas S, Potter ZE, Lu S, Brodsky O, Planken S, Behenna D, Almaden C, Gajiwala KS, Ryan K, Ferre R, Lazear MR, Hayward MM, Kath JC, Cravatt BF. Niessen S, et al. Among authors: lazear mr. Cell Chem Biol. 2017 Nov 16;24(11):1388-1400.e7. doi: 10.1016/j.chembiol.2017.08.017. Epub 2017 Sep 28. Cell Chem Biol. 2017. PMID: 28965727 Free PMC article.
A proteome-wide atlas of lysine-reactive chemistry.
Abbasov ME, Kavanagh ME, Ichu TA, Lazear MR, Tao Y, Crowley VM, Am Ende CW, Hacker SM, Ho J, Dix MM, Suciu R, Hayward MM, Kiessling LL, Cravatt BF. Abbasov ME, et al. Among authors: lazear mr. Nat Chem. 2021 Nov;13(11):1081-1092. doi: 10.1038/s41557-021-00765-4. Epub 2021 Sep 9. Nat Chem. 2021. PMID: 34504315 Free PMC article.
Publisher Correction: A proteome-wide atlas of lysine-reactive chemistry.
Abbasov ME, Kavanagh ME, Ichu TA, Lazear MR, Tao Y, Crowley VM, Am Ende CW, Hacker SM, Ho J, Dix MM, Suciu R, Hayward MM, Kiessling LL, Cravatt BF. Abbasov ME, et al. Among authors: lazear mr. Nat Chem. 2021 Nov;13(11):1151. doi: 10.1038/s41557-021-00823-x. Nat Chem. 2021. PMID: 34588639 No abstract available.