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Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
Martin SES, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, Boutz PL, Törk L, Moss FA, Thomas CJ, Gygi SP, Lazarus MB, Walker S. Martin SES, et al. Among authors: lazarus mb. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545. doi: 10.1021/jacs.8b07328. Epub 2018 Oct 4. J Am Chem Soc. 2018. PMID: 30285435 Free PMC article.
HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Lazarus MB, Jiang J, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. Lazarus MB, et al. Science. 2013 Dec 6;342(6163):1235-9. doi: 10.1126/science.1243990. Science. 2013. PMID: 24311690 Free PMC article.
A small molecule that inhibits OGT activity in cells.
Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. Ortiz-Meoz RF, et al. Among authors: lazarus mb. ACS Chem Biol. 2015 Jun 19;10(6):1392-7. doi: 10.1021/acschembio.5b00004. Epub 2015 Mar 18. ACS Chem Biol. 2015. PMID: 25751766 Free PMC article.
How the glycosyltransferase OGT catalyzes amide bond cleavage.
Janetzko J, Trauger SA, Lazarus MB, Walker S. Janetzko J, et al. Among authors: lazarus mb. Nat Chem Biol. 2016 Nov;12(11):899-901. doi: 10.1038/nchembio.2173. Epub 2016 Sep 12. Nat Chem Biol. 2016. PMID: 27618188 Free PMC article.
29 results