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FFAR from the Gut Microbiome Crowd: SCFA Receptors in T1D Pathology.
Priyadarshini M, Lednovich K, Xu K, Gough S, Wicksteed B, Layden BT. Priyadarshini M, et al. Among authors: layden bt. Metabolites. 2021 May 11;11(5):302. doi: 10.3390/metabo11050302. Metabolites. 2021. PMID: 34064625 Free PMC article. Review.
An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion.
Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, Layden BT. Priyadarshini M, et al. Among authors: layden bt. Mol Endocrinol. 2015 Jul;29(7):1055-66. doi: 10.1210/me.2015-1007. Epub 2015 Jun 15. Mol Endocrinol. 2015. PMID: 26075576 Free PMC article.
The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis.
Fuller M, Priyadarshini M, Gibbons SM, Angueira AR, Brodsky M, Hayes MG, Kovatcheva-Datchary P, Bäckhed F, Gilbert JA, Lowe WL Jr, Layden BT. Fuller M, et al. Among authors: layden bt. Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E840-51. doi: 10.1152/ajpendo.00171.2015. Epub 2015 Sep 22. Am J Physiol Endocrinol Metab. 2015. PMID: 26394664 Free PMC article.
SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets?
Priyadarshini M, Wicksteed B, Schiltz GE, Gilchrist A, Layden BT. Priyadarshini M, et al. Among authors: layden bt. Trends Endocrinol Metab. 2016 Sep;27(9):653-664. doi: 10.1016/j.tem.2016.03.011. Epub 2016 Apr 15. Trends Endocrinol Metab. 2016. PMID: 27091493 Free PMC article. Review.
Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival.
Villa SR, Priyadarshini M, Fuller MH, Bhardwaj T, Brodsky MR, Angueira AR, Mosser RE, Carboneau BA, Tersey SA, Mancebo H, Gilchrist A, Mirmira RG, Gannon M, Layden BT. Villa SR, et al. Among authors: layden bt. Sci Rep. 2016 Jun 21;6:28159. doi: 10.1038/srep28159. Sci Rep. 2016. PMID: 27324831 Free PMC article.
115 results