Lawrence MS - Search Results

1

Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes.

Sanchez A, Ortega P, Sakhtemani R, Manjunath L, Oh S, Bournique E, Becker A, Kim K, Durfee C, Temiz NA, Chen XS, Harris RS, Lawrence MS, Buisson R. Sanchez A, et al. Among authors: lawrence ms. Nat Commun. 2024 Mar 18;15(1):2370. doi: 10.1038/s41467-024-45909-5. Nat Commun. 2024. PMID: 38499542 Free PMC article.

2

Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots.

Jalili P, Bowen D, Langenbucher A, Park S, Aguirre K, Corcoran RB, Fleischman AG, Lawrence MS, Zou L, Buisson R. Jalili P, et al. Among authors: lawrence ms. Nat Commun. 2020 Jun 12;11(1):2971. doi: 10.1038/s41467-020-16802-8. Nat Commun. 2020. PMID: 32532990 Free PMC article.

3

An extended APOBEC3A mutation signature in cancer.

Langenbucher A, Bowen D, Sakhtemani R, Bournique E, Wise JF, Zou L, Bhagwat AS, Buisson R, Lawrence MS. Langenbucher A, et al. Among authors: lawrence ms. Nat Commun. 2021 Mar 11;12(1):1602. doi: 10.1038/s41467-021-21891-0. Nat Commun. 2021. PMID: 33707442 Free PMC article.

4

Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.

Butt Y, Sakhtemani R, Mohamad-Ramshan R, Lawrence MS, Bhagwat AS. Butt Y, et al. Among authors: lawrence ms. Nat Commun. 2024 Mar 18;15(1):2369. doi: 10.1038/s41467-024-46231-w. Nat Commun. 2024. PMID: 38499553 Free PMC article.

5

APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.

Buisson R, Lawrence MS, Benes CH, Zou L. Buisson R, et al. Among authors: lawrence ms. Cancer Res. 2017 Sep 1;77(17):4567-4578. doi: 10.1158/0008-5472.CAN-16-3389. Epub 2017 Jul 11. Cancer Res. 2017. PMID: 28698210 Free PMC article.

6

Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features.

Buisson R, Langenbucher A, Bowen D, Kwan EE, Benes CH, Zou L, Lawrence MS. Buisson R, et al. Among authors: lawrence ms. Science. 2019 Jun 28;364(6447):eaaw2872. doi: 10.1126/science.aaw2872. Science. 2019. PMID: 31249028 Free PMC article.

7

Therapy-induced APOBEC3A drives evolution of persistent cancer cells.

Isozaki H, Sakhtemani R, Abbasi A, Nikpour N, Stanzione M, Oh S, Langenbucher A, Monroe S, Su W, Cabanos HF, Siddiqui FM, Phan N, Jalili P, Timonina D, Bilton S, Gomez-Caraballo M, Archibald HL, Nangia V, Dionne K, Riley A, Lawlor M, Banwait MK, Cobb RG, Zou L, Dyson NJ, Ott CJ, Benes C, Getz G, Chan CS, Shaw AT, Gainor JF, Lin JJ, Sequist LV, Piotrowska Z, Yeap BY, Engelman JA, Lee JJ, Maruvka YE, Buisson R, Lawrence MS, Hata AN. Isozaki H, et al. Among authors: lawrence ms. Nature. 2023 Aug;620(7973):393-401. doi: 10.1038/s41586-023-06303-1. Epub 2023 Jul 5. Nature. 2023. PMID: 37407818 Free PMC article.

8

Genome-wide mapping of regions preferentially targeted by the human DNA-cytosine deaminase APOBEC3A using uracil-DNA pulldown and sequencing.

Sakhtemani R, Senevirathne V, Stewart J, Perera MLW, Pique-Regi R, Lawrence MS, Bhagwat AS. Sakhtemani R, et al. Among authors: lawrence ms. J Biol Chem. 2019 Oct 11;294(41):15037-15051. doi: 10.1074/jbc.RA119.008053. Epub 2019 Aug 19. J Biol Chem. 2019. PMID: 31431505 Free PMC article.

9

Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops.

Sakhtemani R, Perera MLW, Hübschmann D, Siebert R, Lawrence MS, Bhagwat AS. Sakhtemani R, et al. Among authors: lawrence ms. Nucleic Acids Res. 2022 May 20;50(9):5145-5157. doi: 10.1093/nar/gkac296. Nucleic Acids Res. 2022. PMID: 35524550 Free PMC article.

10

Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.

Butt Y, Sakhtemani R, Mohamad-Ramshan R, Lawrence MS, Bhagwat AS. Butt Y, et al. Among authors: lawrence ms. bioRxiv [Preprint]. 2023 Aug 2:2023.08.01.551518. doi: 10.1101/2023.08.01.551518. bioRxiv. 2023. PMID: 37577595 Free PMC article. Updated. Preprint.

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