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A purine metabolic checkpoint that prevents autoimmunity and autoinflammation.
Saveljeva S, Sewell GW, Ramshorn K, Cader MZ, West JA, Clare S, Haag LM, de Almeida Rodrigues RP, Unger LW, Iglesias-Romero AB, Holland LM, Bourges C, Md-Ibrahim MN, Jones JO, Blumberg RS, Lee JC, Kaneider NC, Lawley TD, Bradley A, Dougan G, Kaser A. Saveljeva S, et al. Among authors: lawley td. Cell Metab. 2022 Jan 4;34(1):106-124.e10. doi: 10.1016/j.cmet.2021.12.009. Cell Metab. 2022. PMID: 34986329 Free PMC article.
The Clostridium difficile spo0A gene is a persistence and transmission factor.
Deakin LJ, Clare S, Fagan RP, Dawson LF, Pickard DJ, West MR, Wren BW, Fairweather NF, Dougan G, Lawley TD. Deakin LJ, et al. Among authors: lawley td. Infect Immun. 2012 Aug;80(8):2704-11. doi: 10.1128/IAI.00147-12. Epub 2012 May 21. Infect Immun. 2012. PMID: 22615253 Free PMC article.
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice.
Lawley TD, Clare S, Walker AW, Stares MD, Connor TR, Raisen C, Goulding D, Rad R, Schreiber F, Brandt C, Deakin LJ, Pickard DJ, Duncan SH, Flint HJ, Clark TG, Parkhill J, Dougan G. Lawley TD, et al. PLoS Pathog. 2012;8(10):e1002995. doi: 10.1371/journal.ppat.1002995. Epub 2012 Oct 25. PLoS Pathog. 2012. PMID: 23133377 Free PMC article.
Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.
Stacey MA, Marsden M, Pham N TA, Clare S, Dolton G, Stack G, Jones E, Klenerman P, Gallimore AM, Taylor PR, Snelgrove RJ, Lawley TD, Dougan G, Benedict CA, Jones SA, Wilkinson GW, Humphreys IR. Stacey MA, et al. Among authors: lawley td. Cell Host Microbe. 2014 Apr 9;15(4):471-83. doi: 10.1016/j.chom.2014.03.003. Cell Host Microbe. 2014. PMID: 24721575 Free PMC article.
Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.
Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD, Browne HP, Keane JA, Page AJ, Kumasaka N, Kane L, Mottram L, Harcourt K, Hale C, Arends MJ, Gaffney DJ; Sanger Mouse Genetics Project; Dougan G, Lawley TD. Pham TA, et al. Among authors: lawley td. Cell Host Microbe. 2014 Oct 8;16(4):504-16. doi: 10.1016/j.chom.2014.08.017. Epub 2014 Sep 25. Cell Host Microbe. 2014. PMID: 25263220 Free PMC article.
Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells.
Forbester JL, Lees EA, Goulding D, Forrest S, Yeung A, Speak A, Clare S, Coomber EL, Mukhopadhyay S, Kraiczy J, Schreiber F, Lawley TD, Hancock REW, Uhlig HH, Zilbauer M, Powrie F, Dougan G. Forbester JL, et al. Among authors: lawley td. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10118-10123. doi: 10.1073/pnas.1811866115. Epub 2018 Sep 14. Proc Natl Acad Sci U S A. 2018. PMID: 30217896 Free PMC article.
128 results