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IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases.
Sci Transl Med. 2023 Feb 15;15(683):eabj3289. doi: 10.1126/scitranslmed.abj3289. Epub 2023 Feb 15.
Sci Transl Med. 2023.
PMID: 36791209
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
Pizzonero M, Dupont S, Babel M, Beaumont S, Bienvenu N, Blanqué R, Cherel L, Christophe T, Crescenzi B, De Lemos E, Delerive P, Deprez P, De Vos S, Djata F, Fletcher S, Kopiejewski S, L'Ebraly C, Lefrançois JM, Lavazais S, Manioc M, Nelles L, Oste L, Polancec D, Quénéhen V, Soulas F, Triballeau N, van der Aar EM, Vandeghinste N, Wakselman E, Brys R, Saniere L.
Pizzonero M, et al. Among authors: lavazais s.
J Med Chem. 2014 Dec 11;57(23):10044-57. doi: 10.1021/jm5012885. Epub 2014 Dec 1.
J Med Chem. 2014.
PMID: 25380412
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Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis.
Vandeghinste N, Klattig J, Jagerschmidt C, Lavazais S, Marsais F, Haas JD, Auberval M, Lauffer F, Moran T, Ongenaert M, Van Balen M, Dupont S, Lepescheux L, Garcia T, Härtle S, Eyerich K, Fallon PG, Brys R, Steidl S.
Vandeghinste N, et al. Among authors: lavazais s.
J Invest Dermatol. 2018 Jul;138(7):1555-1563. doi: 10.1016/j.jid.2018.01.036. Epub 2018 Feb 21.
J Invest Dermatol. 2018.
PMID: 29474945
Free article.
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Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.
Temal-Laib T, Peixoto C, Desroy N, De Lemos E, Bonnaterre F, Bienvenu N, Picolet O, Sartori E, Bucher D, López-Ramos M, Roca Magadán C, Laenen W, Flower T, Mollat P, Bugaud O, Touitou R, Pereira Fernandes A, Lavazais S, Monjardet A, Borgonovi M, Gosmini R, Brys R, Amantini D, De Vos S, Andrews M.
Temal-Laib T, et al. Among authors: lavazais s.
J Med Chem. 2024 Jan 11;67(1):380-401. doi: 10.1021/acs.jmedchem.3c01428. Epub 2023 Dec 26.
J Med Chem. 2024.
PMID: 38147525
Free PMC article.
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Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases.
Peixoto C, Joncour A, Temal-Laib T, Tirera A, Dos Santos A, Jary H, Bucher D, Laenen W, Pereira Fernandes A, Lavazais S, Delachaume C, Merciris D, Saccomani C, Drennan M, López-Ramos M, Wakselman E, Dupont S, Borgonovi M, Roca Magadan C, Monjardet A, Brys R, De Vos S, Andrews M, Jimenez JM, Amantini D, Desroy N.
Peixoto C, et al. Among authors: lavazais s.
J Med Chem. 2024 Apr 11;67(7):5233-5258. doi: 10.1021/acs.jmedchem.3c02246. Epub 2024 Mar 29.
J Med Chem. 2024.
PMID: 38552030
Free PMC article.
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A randomized, double-blind comparison between parecoxib sodium and propacetamol for parenteral postoperative analgesia after inguinal hernia repair in adult patients.
Beaussier M, Weickmans H, Paugam C, Lavazais S, Baechle JP, Goater P, Buffin A, Loriferne JF, Perier JF, Didelot JP, Mosbah A, Said R, Lienhart A.
Beaussier M, et al. Among authors: lavazais s.
Anesth Analg. 2005 May;100(5):1309-1315. doi: 10.1213/01.ANE.0000150972.88708.13.
Anesth Analg. 2005.
PMID: 15845675
Clinical Trial.
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[Improvement in swallowing difficulties treated by subcutaneous apomorphine infusion after deep brain stimulation in Parkinson's disease].
Bailbé M, Bataille B, Paquereau J, Lavazais S, Vandermarcq P, Gil R.
Bailbé M, et al. Among authors: lavazais s.
Rev Neurol (Paris). 2004 Mar;160(3):352-3. doi: 10.1016/s0035-3787(04)70913-3.
Rev Neurol (Paris). 2004.
PMID: 15037851
French.
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Choice of the hypnotic and the opioid for rapid-sequence induction.
Lavazais S, Debaene B.
Lavazais S, et al.
Eur J Anaesthesiol Suppl. 2001;23:66-70.
Eur J Anaesthesiol Suppl. 2001.
PMID: 11766250
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