Laurila JM - Search Results

1

Learning Impact of a Virtual Brain Electrical Activity Simulator Among Neurophysiology Students: Mixed-Methods Intervention Study.

Björn MH, Laurila JM, Ravyse W, Kukkonen J, Leivo S, Mäkitalo K, Keinonen T. Björn MH, et al. Among authors: laurila jm. JMIR Serious Games. 2020 Dec 30;8(4):e18768. doi: 10.2196/18768. JMIR Serious Games. 2020. PMID: 33377872 Free PMC article.

2

Deciphering Imidazoline Off-targets by Fishing in the Class A of GPCR field.

Djikic T, Vucicevic J, Laurila J, Radi M, Veljkovic N, Xhaard H, Nikolic K. Djikic T, et al. Mol Inform. 2020 Jul;39(7):e1900165. doi: 10.1002/minf.201900165. Epub 2020 Mar 10. Mol Inform. 2020. PMID: 32078760

3

Homogeneous GTP binding assay employing QRET technology.

Rozwandowicz-Jansen A, Laurila J, Martikkala E, Frang H, Hemmilä I, Scheinin M, Hänninen P, Härmä H. Rozwandowicz-Jansen A, et al. J Biomol Screen. 2010 Mar;15(3):261-7. doi: 10.1177/1087057109358921. Epub 2010 Jan 26. J Biomol Screen. 2010. PMID: 20103692

4

Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha 2-adrenoceptors.

Ruuskanen JO, Laurila J, Xhaard H, Rantanen VV, Vuoriluoto K, Wurster S, Marjamäki A, Vainio M, Johnson MS, Scheinin M. Ruuskanen JO, et al. Br J Pharmacol. 2005 Jan;144(2):165-77. doi: 10.1038/sj.bjp.0706057. Br J Pharmacol. 2005. PMID: 15655522 Free PMC article.

5

Model structures of alpha-2 adrenoceptors in complex with automatically docked antagonist ligands raise the possibility of interactions dissimilar from agonist ligands.

Xhaard H, Nyrönen T, Rantanen VV, Ruuskanen JO, Laurila J, Salminen T, Scheinin M, Johnson MS. Xhaard H, et al. J Struct Biol. 2005 May;150(2):126-43. doi: 10.1016/j.jsb.2004.12.008. J Struct Biol. 2005. PMID: 15866736

6

Transfer of SAR information from hypotensive indazole to indole derivatives acting at α-adrenergic receptors: In vitro and in vivo studies.

Sączewski J, Hudson A, Scheinin M, Wasilewska A, Sączewski F, Rybczyńska A, Ferdousi M, Laurila JM, Boblewski K, Lehmann A, Watts H, Ma D. Sączewski J, et al. Among authors: laurila jm. Eur J Med Chem. 2016 Jun 10;115:406-15. doi: 10.1016/j.ejmech.2016.03.026. Epub 2016 Mar 14. Eur J Med Chem. 2016. PMID: 27031216

7

Fluorinated analogues of marsanidine, a highly α2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities.

Wasilewska A, Sączewski F, Hudson AL, Ferdousi M, Scheinin M, Laurila JM, Rybczyńska A, Boblewski K, Lehmann A. Wasilewska A, et al. Among authors: laurila jm. Eur J Med Chem. 2014 Nov 24;87:386-97. doi: 10.1016/j.ejmech.2014.09.083. Epub 2014 Sep 28. Eur J Med Chem. 2014. PMID: 25282262

8

Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior.

Gentili F, Cardinaletti C, Vesprini C, Carrieri A, Ghelfi F, Farande A, Giannella M, Piergentili A, Quaglia W, Laurila JM, Huhtinen A, Scheinin M, Pigini M. Gentili F, et al. Among authors: laurila jm. J Med Chem. 2008 Jul 24;51(14):4289-99. doi: 10.1021/jm800250z. Epub 2008 Jun 25. J Med Chem. 2008. PMID: 18578476

9

Octopamine receptors from the barnacle balanus improvisus are activated by the alpha2-adrenoceptor agonist medetomidine.

Lind U, Alm Rosenblad M, Hasselberg Frank L, Falkbring S, Brive L, Laurila JM, Pohjanoksa K, Vuorenpää A, Kukkonen JP, Gunnarsson L, Scheinin M, Mårtensson Lindblad LG, Blomberg A. Lind U, et al. Among authors: laurila jm. Mol Pharmacol. 2010 Aug;78(2):237-48. doi: 10.1124/mol.110.063594. Epub 2010 May 20. Mol Pharmacol. 2010. PMID: 20488921

10

Synthesis and biological activities of 2-[(heteroaryl)methyl]imidazolines.

Saczewski J, Hudson A, Scheinin M, Rybczynska A, Ma D, Saczewski F, Laird S, Laurila JM, Boblewski K, Lehmann A, Gu J, Watts H. Saczewski J, et al. Among authors: laurila jm. Bioorg Med Chem. 2012 Jan 1;20(1):108-16. doi: 10.1016/j.bmc.2011.11.025. Epub 2011 Nov 25. Bioorg Med Chem. 2012. PMID: 22172308

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