Laurila J - Search Results

1

Deciphering Imidazoline Off-targets by Fishing in the Class A of GPCR field.

Djikic T, Vucicevic J, Laurila J, Radi M, Veljkovic N, Xhaard H, Nikolic K. Djikic T, et al. Among authors: laurila j. Mol Inform. 2020 Jul;39(7):e1900165. doi: 10.1002/minf.201900165. Epub 2020 Mar 10. Mol Inform. 2020. PMID: 32078760

2

Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha 2-adrenoceptors.

Ruuskanen JO, Laurila J, Xhaard H, Rantanen VV, Vuoriluoto K, Wurster S, Marjamäki A, Vainio M, Johnson MS, Scheinin M. Ruuskanen JO, et al. Among authors: laurila j. Br J Pharmacol. 2005 Jan;144(2):165-77. doi: 10.1038/sj.bjp.0706057. Br J Pharmacol. 2005. PMID: 15655522 Free PMC article.

3

Model structures of alpha-2 adrenoceptors in complex with automatically docked antagonist ligands raise the possibility of interactions dissimilar from agonist ligands.

Xhaard H, Nyrönen T, Rantanen VV, Ruuskanen JO, Laurila J, Salminen T, Scheinin M, Johnson MS. Xhaard H, et al. Among authors: laurila j. J Struct Biol. 2005 May;150(2):126-43. doi: 10.1016/j.jsb.2004.12.008. J Struct Biol. 2005. PMID: 15866736

4

Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior.

Gentili F, Cardinaletti C, Vesprini C, Carrieri A, Ghelfi F, Farande A, Giannella M, Piergentili A, Quaglia W, Laurila JM, Huhtinen A, Scheinin M, Pigini M. Gentili F, et al. J Med Chem. 2008 Jul 24;51(14):4289-99. doi: 10.1021/jm800250z. Epub 2008 Jun 25. J Med Chem. 2008. PMID: 18578476

5

Fluorinated analogues of marsanidine, a highly α2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities.

Wasilewska A, Sączewski F, Hudson AL, Ferdousi M, Scheinin M, Laurila JM, Rybczyńska A, Boblewski K, Lehmann A. Wasilewska A, et al. Eur J Med Chem. 2014 Nov 24;87:386-97. doi: 10.1016/j.ejmech.2014.09.083. Epub 2014 Sep 28. Eur J Med Chem. 2014. PMID: 25282262

6

Homogeneous GTP binding assay employing QRET technology.

Rozwandowicz-Jansen A, Laurila J, Martikkala E, Frang H, Hemmilä I, Scheinin M, Hänninen P, Härmä H. Rozwandowicz-Jansen A, et al. Among authors: laurila j. J Biomol Screen. 2010 Mar;15(3):261-7. doi: 10.1177/1087057109358921. Epub 2010 Jan 26. J Biomol Screen. 2010. PMID: 20103692

7

3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the α(2)-adrenoceptor compared to the imidazoline I(1) receptor.

Sączewski F, Kornicka A, Hudson AL, Laird S, Scheinin M, Laurila JM, Rybczyńska A, Boblewski K, Lehmann A, Gdaniec M. Sączewski F, et al. Bioorg Med Chem. 2011 Jan 1;19(1):321-9. doi: 10.1016/j.bmc.2010.11.020. Epub 2010 Nov 11. Bioorg Med Chem. 2011. PMID: 21129985

8

Transfer of SAR information from hypotensive indazole to indole derivatives acting at α-adrenergic receptors: In vitro and in vivo studies.

Sączewski J, Hudson A, Scheinin M, Wasilewska A, Sączewski F, Rybczyńska A, Ferdousi M, Laurila JM, Boblewski K, Lehmann A, Watts H, Ma D. Sączewski J, et al. Among authors: laurila jm. Eur J Med Chem. 2016 Jun 10;115:406-15. doi: 10.1016/j.ejmech.2016.03.026. Epub 2016 Mar 14. Eur J Med Chem. 2016. PMID: 27031216

9

Octopamine receptors from the barnacle balanus improvisus are activated by the alpha2-adrenoceptor agonist medetomidine.

Lind U, Alm Rosenblad M, Hasselberg Frank L, Falkbring S, Brive L, Laurila JM, Pohjanoksa K, Vuorenpää A, Kukkonen JP, Gunnarsson L, Scheinin M, Mårtensson Lindblad LG, Blomberg A. Lind U, et al. Mol Pharmacol. 2010 Aug;78(2):237-48. doi: 10.1124/mol.110.063594. Epub 2010 May 20. Mol Pharmacol. 2010. PMID: 20488921

10

Synthesis and biological activities of 2-[(heteroaryl)methyl]imidazolines.

Saczewski J, Hudson A, Scheinin M, Rybczynska A, Ma D, Saczewski F, Laird S, Laurila JM, Boblewski K, Lehmann A, Gu J, Watts H. Saczewski J, et al. Among authors: laurila jm. Bioorg Med Chem. 2012 Jan 1;20(1):108-16. doi: 10.1016/j.bmc.2011.11.025. Epub 2011 Nov 25. Bioorg Med Chem. 2012. PMID: 22172308

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