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Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.
Métifiot M, Johnson BC, Kiselev E, Marler L, Zhao XZ, Burke TR Jr, Marchand C, Hughes SH, Pommier Y. Métifiot M, et al. Among authors: marler l. Nucleic Acids Res. 2016 Aug 19;44(14):6896-906. doi: 10.1093/nar/gkw592. Epub 2016 Jul 1. Nucleic Acids Res. 2016. PMID: 27369381 Free PMC article.
Antiproliferative and quinone reductase-inducing activities of withanolides derivatives.
García ME, Nicotra VE, Oberti JC, Ríos-Luci C, León LG, Marler L, Li G, Pezzuto JM, van Breemen RB, Padrón JM, Hueso-Falcón I, Estévez-Braun A. García ME, et al. Among authors: marler l. Eur J Med Chem. 2014 Jul 23;82:68-81. doi: 10.1016/j.ejmech.2014.05.045. Epub 2014 May 20. Eur J Med Chem. 2014. PMID: 24878636
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